摘要
目的探讨疏血通注射液对胸腰椎骨折术后血栓的预防效果。方法选取160例2020年10月—2021年10月该院收治的胸腰椎骨折后路椎弓根钉棒系统固定术后患者作为研究对象,以随机数字表法将160例患者分为对照组(80例)和观察组(80例)。对照组给予低分子肝素钙注射液进行治疗,观察组在对照组的基础上给予疏血通注射液进行治疗,两组均持续治疗2周,随访3个月。比较两组术后恢复情况,治疗1 d、治疗2周后的症状评分,治疗前、治疗2周后的疼痛程度、日常活动能力及凝血功能。结果治疗2周后,观察组血栓形成率为3.75%(3/80),低于对照组的13.75%(11/80);观察组骨折愈合时间及住院时间均短于对照组(P<0.05)。与治疗1 d后比较,治疗2周后,两组瘀斑面积、肿胀情况评分均降低,且观察组低于对照组(P<0.05)。与治疗前比较,治疗2周后,两组视觉模拟评分法(VAS)、Oswestry功能障碍指数(ODI)评分及全血D-二聚体(D-D)、血栓前体蛋白(TpP)、凝血酶原时间(PT)、部分凝血活酶时间(APTT)水平均降低,且观察组低于对照组(P<0.05)。结论疏血通注射液可改善胸腰椎骨折术后患者凝血功能,减轻患者疼痛程度,进而有助于促进患者临床症状的恢复,预防患者术后血栓形成,疗效显著。
Objective To investigate the preventive effect of Shuxuetong Injection(疏血通注射液)on thrombosis after thoracolumbar fractures.Methods A total of 160 patients with thoracolumbar fractures treated in the hospital from October 2020 to October 2021 after posterior pedicle screw-rod system fixation were selected as the research objects,and the patients were divided into the control group(80 cases)and the observation group(80 cases)by random number table method.The control group was given low molecular weight heparin calcium injection for treatment,and the observation group was given Shuxuetong Injection on the basis of the control group.Both groups were treated for 2 weeks and followed up for 3 months.The postoperative recovery,symptom scores after 1 d and 2 weeks of treatment,the pain,the daily activity ability and the coagulation function before and after 2 weeks of treatment were compared between the two groups.Results After 2 weeks of treatment,the thrombosis rate in the observation group was 3.75%(3/80),which was lower than 13.75%(11/80)in the control group.The times of fracture healing and hospital stay in the observation group were shorter than those in the control group(P<0.05).Compared with 1 d and 2 weeks of treatment,the scores of ecchymosis area and swelling in the two groups decreased,and the scores of the observation group were lower than those of the control group(P<0.05).Compared with before treatment and after 2 weeks of treatment,the scores of visual analogue scale(VAS),Oswestry disability index(ODI),whole blood D-dimer(DD),thrombus precursor protein(TpP),prothrombin time(PT)and partial thromboplastin time(APTT)decreased,and those of the observation group were lower than those of the control group(P<0.05).Conclusion Shuxuetong Injection could improve the coagulation function of patients after thoracolumbar fractures,reduce the pain of patients,and then help to promote the recovery of clinical symptoms of patients and prevent postoperative thrombosis of patients,with significant curative effec
作者
黄俊利
柴必栋
柯丽秀
张青
HUANG Junli;CHAI Bidong;KE Lixiu;ZHANG Qing(Zhangjiakou Second Hospital,Zhangjiakou 075000,Hebei,China)
出处
《辽宁中医杂志》
CAS
2023年第8期143-146,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
胸腰椎骨折
后路椎弓根钉棒系统固定术
疏血通注射液
低分子肝素钙
血栓
凝血功能
thoracolumbar fractures
posterior pedicle screw-rod system fixation
Shuxuetong Injection(疏血通注射液)
low molecular weight heparin calcium
thrombosis
coagulation function
