摘要
目的评估清肾排毒方结合复方α-酮酸治疗慢性肾衰的疗效与安全性。方法将76例慢性肾衰患者(2019年2月—2022年6月收治以随机数字表法分为参照组、中药组,各38例,参照组患者采取复方α-酮酸治疗,中药组患者在参照组治疗基础上联合中药清肾排毒方灌肠治疗,治疗1个月。数据比较:疗效与不良反应、治疗前后中医证候总积分变化、症状改善时间(气短、乏力、食欲不振、体力下降)、治疗前后尿素氮(BUN)、尿酸(UA)、血清肌酐(Scr)、内生肌酐清除率(Ccr)指标变化、白蛋白(ALB)、血红蛋白(HB)水平变化。结果中药组总有效率比参照组患者更高[92.11%(35/38)vs 73.68%(28/38)],差异有统计学意义(P<0.05);中药组不良反应率与参照组比较[2.63%(1/38)vs5.26%(2/38)],差异无统计学意义(P>0.05);治疗前,各组患者中医证候总积分以及BUN、UA、Scr、Ccr、ALB、HB等指标比较,差异无统计学意义(P>0.05)。治疗后各组患者中医证候总积分以及BUN、UA、Scr、Ccr、ALB、HB等指标均改善,中药组患者治疗后中医证候总积分以及BUN、UA、Scr、Ccr、ALB、HB等指标均优于参照组患者,差异有统计学意义(P<0.05);中药组患者症状改善时间(气短、乏力、食欲不振、体力下降)均短于参照组,差异有统计学意义(P<0.05)。结论清肾排毒方结合复方α-酮酸治疗慢性肾衰的疗效确切,患者肾功能改善,症状改善,营养状况提升,值得应用。
Objective To evaluate the efficacy and safety of combination of Qingshen Paidu Recipe(清肾排毒方)and compoundα-ketoacids in the treatment of chronic renal failure.Methods 76 patients with chronic renal failure(admitted from February 2019 to June 2022)were randomly divided into the reference group and the traditional Chinese medicine group with 38 cases in each.The patients in the reference group were treated with compoundα-ketoacid and those in the trational Chinese medicine group were treated with Qingshen Paidu Recipe enema on the basis of the treatment in the reference group for one month.The data was compared,including the efficacy and adverse reactions,the change of the total score of TCM syndromes before and after treatment,the time of symptom improvement(shortness of breath,fatigue,loss of appetite,physical decline),the change of urea nitrogen(BUN),uric acid(UA),serum creatinine(SCR),endogenous creatinine clearance rate(CCR),albumin(ALB)and hemoglobin(HB)before and after treatment.Results The total effective rate of the traditional Chinese medicine group was higher than that of the reference group[92.11%(35/38)vs 73.68%(28/38),P<0.05].The adverse reaction rate of the traditional Chinese medicine group was compared with that of the reference group(2.63%vs 5.26%,P>0.05).Before treatment,the total score of TCM syndromes and the levels of BUN,UA,SCR,CCR,ALB,Hb and other indicators of patients in each group were not significantly different(P>0.05).After treatment,the total score of TCM syndromes and the levels of BUN,UA,SCR,CCR,ALB,Hb and other indicators of patients in each group were improved,and the total score of TCM syndromes and the levels of BUN,UA,SCR,CCR,ALB,Hb and other indicators of patients in the traditional Chinese medicine group were better than those in the reference group(P<0.05).The improvement time of symptoms(shortness of breath,fatigue,loss of appetite,physical decline)in the traditional Chinese medicine group was shorter than that in the reference group(P<0.05).Conclusion Qingshen P
作者
王君
马倩
刘诗富
WANG Jun;MA Qian;LIU Shifu(Department of Nephrology,Wuhu Hospital of Traditional Chinese Medicine,Wuhu 241000,Hubei,Anhui;Department of Nephrology,Huzhou Hospital of Traditional Chinese Medicine,Huzhou 313008,Zhejiang,China)
出处
《辽宁中医杂志》
CAS
2023年第8期104-107,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
安徽省重点研究与开发计划项目(202104j07020014)。
关键词
慢性肾衰
复方Α-酮酸
清肾排毒方
疗效
肾功能
chronic renal failure
compoundα-ketoacids
Qingshen Paidu Recipe(清肾排毒方)
curative effect
renal function
