摘要
目的探讨血清甲状旁腺激素(PTH)联合N端B型-脑利纳肽前体(NT-proBNP)检测在老年急性心力衰竭(AHF)患者中的诊断价值。方法选取2021年10月至2022年10月山东大学齐鲁医院接诊的115例老年AHF患者作为研究组,并根据其严重程度分为轻度组(n=31)、中度组(n=56)、重度组(n=28),另外选取同期行健康体检的110名正常老年人作为参照组。采集空腹静脉血并测定所有受试者的PTH、NT-proBNP,比较两组受试者的PTH、NT-proBNP水平及不同程度AHF患者的PTH、NT-proBNP水平,并分析PTH、NT-proBNP单独和联合检测诊断老年AHF的效能。结果研究组患者的PTH、NT-proBNP水平均高于参照组,差异有统计学意义(P<0.05)。不同病情程度的老年AHF患者血清PTH、NT-proBNP水平比较,差异有统计学意义(P<0.05),其中重度组的PTH、NT-proBNP高于中度组和轻度组,中度组的PTH、NT-proBNP高于轻度组,差异有统计学意义(P<0.05)。三种检测方法诊断老年AHF的灵敏度、阴性预测值及准确性比较,差异有统计学意义(P<0.05);联合检测诊断老年AHF的灵敏度和阴性预测值高于PTH、NT-proBNP单独检测,准确性高于PTH单独检测,差异有统计学意义(P<0.017)。结论血清PTH联合NT-proBNP检测进行老年AHF诊断能提高诊断的准确性,还能在一定程度为病情严重程度的评估分级提供参考依据。
Objective To investigate the value of serum parathyroid hormone(PTH)combined with N-terminal B-brain lineptide precursor(NT-proBNP)in the diagnosis of elderly patients with acute heart failure(AHF).Methods A total of 115 elderly patients with AHF admitted to Qilu Hospital of Shandong University from October 2021 to October 2022 were selected as the study group,and divided into mild group(n=31),moderate group(n=56)and severe group(n=28)according to their severity.In addition,110 normal elderly patients who underwent physical examination during the same period were selected as the reference group.Fasting venous blood was collected and PTH and NT-proBNP levels of all subjects were measured,PTH and NT-proBNP levels of subjects in the two groups were compared and PTH and NT-proBNP levels of patients with different degrees of AHF were compared,and the efficacy of PTH and NT-proBNP alone and combined detection in the diagnosis of elderly AHF was analyzed.Results The levels of PTH and NT-proBNP in the study group were higher than those in the reference group,and the differences were statistically significant(P<0.05).The serum PTH and NT-proBNP levels of elderly AHF patients with different disease degrees were compared,and the difference was statistically significant(P<0.05).The PTH and NT-proBNP levels in the severe group were higher than those in the moderate group and the mild group,and the PTH and NT-proBNP levels in the moderate group were higher than those in the mild group,and the differences were statistically significant(P<0.05).The sensitivity,negative predictive value and accuracy of the three methods in the diagnosis of AHF in the elderly were compared,and the differences were statistically significant(P<0.05).The sensitivity and negative predictive value of combined detection in the diagnosis of elderly AHF were higher than that of PTH and NT-proBNP alone detection,and the accuracy was higher than that of PTH alone detection,the differences were statistically significant(P<0.017).Conclusion The combination of
作者
王春娥
WANG Chun′e(Department of Stomatology,Qilu Hospital of Shandong University,Shandong Province,Jinan250012,China)
出处
《中国当代医药》
CAS
2023年第25期76-79,共4页
China Modern Medicine
