摘要
目的调查天津市体检人群甲状腺结节(TNs)患病情况,分析代谢综合征(MetS)与TNs间的相关性。方法选择2019年1月1日至2020年12月31日在天津市武清区第二人民医院体检者进行回顾性横断面研究。收集研究对象一般检查、实验室检查、多普勒超声检查等资料。采用Logistic回归模型分析MetS与TNs发生风险的关系。结果本研究共纳入12359例研究对象。TNs总患病率为46.8%(5781例),其中高危结节309例(5.3%),非高危结节5472例(94.7%)。女性患病率(48.6%)明显高于男性(44.9%)(χ^(2)=17.01,P<0.001)。多因素Logistic回归模型显示性别(OR=1.511)、年龄(OR=1.472)、MetS(OR=1.272)是TNs独立危险因素(P<0.05)。女性高血糖和高血压患者在高危结节组(高血糖OR=2.59,高血压OR=1.805,P<0.05)显示出比非高危结节组(高血糖OR=1.527,高血压OR=1.309,P<0.05)更高的患病风险。结论体检人群TNs患病率较高,女性、高龄、MetS是TNs发生的独立危险因素。此外,高血糖和高血压等代谢性因素进一步增加了女性甲状腺高危结节的患病风险。
Objective To investigate the prevalence of thyroid nodules(TNs)in health check-up population in Tianjin and analyze the correlation between metabolic syndrome(MetS)and TNs.Methods A retrospective cross-sectional study was conducted by selecting the health check-up subjects from January 1,2019 to December 31,2020 in Wuqing District Second People's Hospital,Tianjin.The data of general examination,laboratory tests and Doppler ultrasonography from the subjects were collected.Logistic regression model was used to analyze the correlation between MetS and the risk factors of TNs.ResultsA total of 12359 subjects were enrolled in this study.The overall prevalence of TNs was 46.8%(5781 cases),including 309(5.3%)high-risk nodes and 5472(94.7%)non-highrisk nodes.The prevalence of TNs in females(48.6%)was significantly higher than that in males(44.9%)(χ^(2)=17.01,P<0.001).Multifactorial Logistic regression model showed that gender(OR=1.511),age(OR=1.472)and MetS(OR=1.272)were the independent risk factors for TNs(P<0.05).The risk of developing thyroid nodules in the female patients with hyperglycemia and hypertension of the high-risk nodules group was higher(OR of hyperglycemia=2.59,OR of hypertension=1.805,P<0.05)than that in the non-high-risk nodules group(OR of hyperglycemia=1.527,OR of hypertension=1.309,P<0.05).Conclusion The prevalence rate of TNs was relatively higher in health check-up population.For the development of TNs,females,age and MetS should be the independent risk factors.In addition,the metabolic factors,such as hyperglycemia and hypertension,may further increase the developing risk of high-risk thyroid nodules in females.
作者
赵雪松
王德强
侯隽
郭腾蛟
马志欣
张强
ZHAO Xuesong;WANG Deqiang;HOU Jun;GUO Tengjiao;MA Zhixin;ZHANG Qiang(Department of Clinical Laboratory,Tianjin Wuqing District Second People's Hospital,Tianjin301725;Department of Clinical Laboratory,Branch of Tianjin Third Central Hospital,Tianjin300250;Tianjin Geriatrics Institute,Tianjin300250,China)
出处
《临床检验杂志》
CAS
2023年第6期457-461,共5页
Chinese Journal of Clinical Laboratory Science
基金
科技部国家重点研发计划(2019YFF0216502)
天津市卫生健康委员会、天津市中医药管理局中医中西医结合科研课题(2021189)。
关键词
甲状腺结节
代谢综合征
体检
患病率
风险因素
thyroid nodules
metabolic syndrome
health check-up
prevalence rate
risk factors
