摘要
目的探讨仁青芒觉胶囊联合雷贝拉唑治疗胃溃疡的临床疗效。方法选取2020年3月-2023年2月首都医科大学附属北京康复医院收治的91例胃溃疡患者,按随机数字表法将所有患者分为对照组(45例)和治疗组(46例)。对照组晨服雷贝拉唑钠肠溶片,20 mg/次,1次/d。治疗组在对照组基础上口服仁青芒觉胶囊,4粒/次,1次/d。两组疗程均为6周。观察两组临床疗效,比较治疗前后两组主要症状积分、溃疡愈合率和幽门螺杆菌(Hp)根除率、36项健康调查简表(SF-36)评分及血清胃泌素(GAS)、胃动素(MTL)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β1(TGF-β1)水平。结果治疗后,治疗组总有效率是95.65%,较对照组的80.00%显著提高(P<0.05)。治疗后,两组中上腹痛、反酸、嗳气、脘腹胀满积分及其总积分均较治疗前显著降低(P<0.05);且治疗后,治疗组主要症状积分显著低于对照组(P<0.05)。治疗后,治疗组溃疡愈合率、Hp根除率分别为73.91%、89.13%,均显著高于对照组的51.11%、71.11%(P<0.05)。治疗后,两组SF-36中生理健康评分、心理健康评分及量表总分均显著增加(P<0.05);且治疗后,治疗组SF-36评分高于对照组(P<0.05)。治疗后,两组GAS、MTL、TNF-α、TGF-β1水平均较治疗前显著下降(P<0.05);且治疗后,治疗组血清GAS、MTL、TNF-α、TGF-β1水平均显著低于对照组(P<0.05)。结论仁青芒觉胶囊联合雷贝拉唑治疗胃溃疡可获得确切疗效,能安全有效地缓解患者主要症状,调节胃肠激素,抑制炎症反应,促进溃疡愈合及Hp清除,改善生活质量,值得临床推广应用。
Objective To explore the clinical efficacy of Renqing Mangjue Capsules combined with rabeprazole in treatment of gastric ulcers.Methods A total of 91 patients with gastric ulcer admitted to Beijing Rehabilitation Hospital Affiliated to Capital Medical University from March 2020 to February 2023 were selected and divided into control group(45 cases)and treatment group(46 cases)according to random number table method.Patients in the control group were po administered with Sodium Rabeprazole Enteric-coated Tablets,20 mg/time,once daily.Patients in the treatment group were po administered with Renqing Mangjue Capsules on the basis of the control group,4 grains/time,once daily.Patients in two groups were treated for 6 weeks.After treatment,the clinical efficacy was evaluated,and the score of major symptoms,ulcer healing rate,Hp eradication rate,36 health survey summary table(SF-36)score and serum gastrin(GAS),motilin(MTL),tumor necrosis factor-α(TNF-α),transforming growth factor-β1(TGF-β1)levels were compared before and after treatment.Results After treatment,the total effective rate of the treatment group was 95.65%,which was significantly higher than that of the control group(80.00%,P<0.05).After treatment,the scores of middle and upper abdominal pain,acid regurgitation,belching,abdominal distension and their total scores were significantly decreased in both groups compared with before treatment(P<0.05).After treatment,the main symptom score of the treatment group was significantly lower than that of the control group(P<0.05).After treatment,the ulcer healing rate and Hp eradication rate in the treatment group were 73.91%and 89.13%,respectively,which were significantly higher than 51.11%and 71.11%in the control group(P<0.05).After treatment,the physical health score,mental health score and total score of SF-36 in two groups were significantly increased(P<0.05).After treatment,the SF-36 score of the treatment group was higher than that of the control group(P<0.05).After treatment,serum GAS,MTL,TNF-αand TGF-β1 l
作者
薛梅
薛伟
张梦巧
贾伟
魏秀芹
XUE Mei;XUE Wei;ZHANG Meng-qiao;JIA Wei;WEI Xiu-qin(Beijing Rehabilitation Hospital Affiliated to Capital Medical University,Beijing 100144,China;The Sixth People's Hospital of Huangdao District in Qingdao,Qingdao 266419,China)
出处
《现代药物与临床》
CAS
2023年第8期1971-1976,共6页
Drugs & Clinic
基金
首都医科大学附属北京康复医院科技发展专项(2020-036)。
