摘要
E3泛素连接酶是泛素-蛋白酶体系统中不可缺少的一大类酶,根据催化核心结构域可分为HECT E3s、 U-box E3s、RING E3s三大家族,其中RING E3s又可分为TRIM、PA-TM-RING、RBR、MARCH和UIM五个家族。真核生命的一切生物行为都离不开泛素的修饰,而E3泛素连接酶则通过介导泛素-E2泛素连接酶将泛素传递给靶蛋白,能严格控制泛素化反应。因此,E3泛素连接酶可能参与调节细胞增殖等生物过程和细胞对与癌症发展相关的应激信号的反应,可以成为多种癌症治疗的有希望的靶点。因此,本文对E3泛素连接酶的分类、功能及在肿瘤中的作用进行综述。
E3 ubiquitin ligase is an indispensable class of enzymes in the ubiquitin-proteasome system,which can be divided into HECT E3s,U-box E3s,and RING E3s.According to the catalytic core domain,of which RING E3s can be divided into TRIM,PA-TM-RING,RBR,MARCH and UIM.The key is that all biological behaviors of eukaryotic life are inseparable from the modification of ubiquitin,and E3 ubiquitin ligase can strictly control the ubiquitination reaction by mediating ubiquitin-E2 ubiquitin ligase to deliver ubiquitin to the target protein.Thus,E3 ubiquitin ligase may be involved in regulating biological processes such as cell proliferation and cellular responses to stress signals associated with cancer development,and could be a promising target for a variety of cancer treatments.Therefore,this article reviews the classification,function and role of E3 ubiquitin ligase in tumors.
作者
朱玲媛
吴照球
ZHU Lingyuan;WU Zhaoqiu(School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《生物化工》
CAS
2023年第4期165-171,共7页
Biological Chemical Engineering
关键词
E3泛素连接酶
结构功能
癌症
E3 ubiquitin ligase
structural function
cancer
