摘要
目的探讨颅内动脉瘤介入治疗后复发的危险因素。方法收集2020年1月至2022年2月于重庆大学附属涪陵医院住院接受介入治疗的120例颅内动脉瘤患者的临床资料,根据术后6个月随访结果将患者分为复发组(n=23)和对照组(n=97)。比较两组患者的术前临床特征、动脉瘤影像学检查结果及手术时间,分析颅内动脉瘤介入治疗后复发的危险因素。结果两组患者的吸烟、饮酒、体重指数、收缩压、舒张压、白细胞计数、血红蛋白、血小板计数、谷丙转氨酶、总胆红素、肌酐、总胆固醇、甘油三酯、血糖比较,差异均无统计学意义(P>0.05),但复发组患者的术前C反应蛋白水平高于对照组患者,差异有统计学意义(P<0.05)。复发组患者大型动脉瘤、Raymond分级为Ⅱ~Ⅲ级的比例均高于对照组患者,而使用支架的比例低于对照组患者,差异均有统计学意义(P<0.05);两组患者动脉瘤的部位、瘤颈分型、解剖分型、手术时间比较,差异均无统计学意义(P>0.05)。多因素分析结果显示,瘤体直径>10 mm、Raymond分级为Ⅱ~Ⅲ级、C反应蛋白水平>5 mg/L均是颅内动脉瘤介入治疗后复发的危险因素(P<0.05)。结论大型动脉瘤、Raymond分级为Ⅱ~Ⅲ级及C反应蛋白水平升高均会增加颅内动脉瘤介入治疗后复发的风险。
Objective To investigate the risk factors of recurrence of intracranial aneurysms after interventional therapy.Method The clinical data of 120 patients with intracranial aneurysm who were hospitalized in Chongqing University Fuling Hospital for interventional therapy from January 2020 to February 2022 were collected.Patients were divided into recurrence group(n=23)and control group(n=97)according to the follow-up results at 6 months after surgery.The preoperative clinical characteristics,aneurysm imaging examination results,and operation time were compared between the two groups,risk factors for recurrence after interventional therapy for intracranial aneurysms were also analyzed.Result There were no statistically significant differences in smoking,drinking,body mass index,systolic blood pressure,diastolic blood pressure,white blood cell count,hemoglobin,platelet count,alanine aminotransferase,total bilirubin,creatinine,total cholesterol,triglyceride,and blood sugar between the two groups(P>0.05),but the preoperative C-reactive protein level in the recurrence group was higher than that in the control group,the difference was statistically significant(P<0.05).The proportion of patients with large aneurysms and Raymond grade Ⅱ-Ⅲ in the recurrence group were higher than that of the control group,while the proportion of patients using stents was lower than that of the control group,the differences were statistically significant(P<0.05).There were no significant differences in aneurysm location,aneurysm neck type,anatomical type,and operation time between the two groups(P>0.05).Multivariate analysis showed that diameter>10 mm,Raymond grade Ⅱ-Ⅲ,and C-reactive protein level>5 mg/L were all risk factors for recurrence after the interventional therapy of intracranial aneurysms(P<0.05).Conclusion Large aneurysm,Raymond grades Ⅱ-Ⅲ,and elevated C-reactive protein all increase the risk of intracranial aneurysm recurrence after interventional therapy.
作者
廖鹏
吴小波
张轶行
汪峰
曾礼
邓超
Liao Peng;Wu Xiaobo;Zhang Yixing;Wang Feng;Zeng Li;Deng Chao(Department of Neurosurgery,Chongqing University Fuling Hospital,Chongqing 408099,China)
出处
《血管与腔内血管外科杂志》
2023年第8期992-996,共5页
Journal of Vascular and Endovascular Surgery
关键词
颅内动脉瘤
介入治疗
复发
危险因素
intracranial aneurysm
interventional therapy
recurrence
risk factor
