摘要
Six new lignans(1-6),as well as five known ones(7-11)were isolated from the leaves and stems of Schisandra chinensis.The structures of 1-6 were established on the basis of spectroscopic methods including 1D-and 2D-NMR techniques and CD experiments.Compound 1 was the first example of naturally occurring N-containing lignans featuring a nicotinoyl group.All the new compounds were evaluated for their anti-HIV-1 activities and showed EC50 values in the range 17.89-138.23μg/mL.
基金
the National Natural Science Foundation of China(Nos.81373290,81102483)
the Natural Science Foundation of Yunnan Province(No.2012FB178)
the Chinese Academy of Sciences grant(No.KSCX2-EW-Q-10)
sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry to W.-L.Xiao.
