摘要
目的探讨传统中药干预非典型抗精神病药物所致脂代谢紊乱的疗效。方法采用随机数字表法将2021年1月-2022年6月于江西省第五人民医院接受非典型抗精神病药物治疗且症状基本缓解的精神分裂症(SZ)患者60例分为两组,每组各30例。对照组单纯接受非典型抗精神病药物(奥氮平)治疗,研究组加用荷叶茶治疗,两组均连续治疗6个月。对比两组临床疗效、血脂水平、阳性与阴性症状量表(PANSS)评分及不良反应。结果两组治疗后总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平均升高,但研究组治疗前后TC、TG、HDL-C、LDL-C水平比较,差异不显著(P>0.05),对照组治疗后TC、TG、HDL-C、LDL-C水平高于治疗前(P<0.05);两组治疗后PANSS评分均低于治疗前(P<0.05);但两组治疗后PANSS评分比较,差异不显著(P>0.05);两组不良反应发生率比较,差异不显著(P>0.05)。结论荷叶早期干预接受非典型抗精神病药物治疗的SZ患者可稳定其血脂水平,巩固非典型抗精神病药物的治疗效果,安全性好,利于患者预后。
Objective To explore the therapeutic effect of traditional Chinese medicine intervention on lipid metabolism disorders caused by atypical antipsychotic drugs.Method A random number table method was used to divide 60 patients with schizophrenia(SZ)who received atypical antipsychotic medication treatment in our hospital from January 2021 to June 2022 and whose symptoms were basically relieved into two groups,with 30 patients in each group.The control group was treated with atypical antipsychotic drugs(olanzapine)alone,while the study group was treated with lotus leaf tea.Both groups were treated continuously for 6 months.Compare the clinical efficacy,blood lipid levels,positive and negative symptom scales(PANSS),and adverse reactions between two groups.Results The levels of total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)in the two groups increased after treatment,but the levels of TC,TG,HDL-C and LDL-C in the study group were compared before and after treatment(P>0.05);after treatment,the levels of TC,TG,HDL-C,and LDL-C in the control group were higher than before treatment(P<0.05);after treatment,the PANSS scores of both groups were lower than before treatment(P<0.05);but the comparison of PANSS scores between the two groups after treatment(P>0.05);comparison of the incidence of adverse reactions between the two groups(P>0.05).Conclusion Early intervention with lotus leaf can stabilize blood lipid levels and consolidate the therapeutic effect of atypical antipsychotic drugs in SZ patients receiving treatment with atypical antipsychotic drugs,with good safety and favorable prognosis.
作者
毛颖婕
毕丽叶
陈亦庆
罗妮娜
钟笑
Mao Yingjie;Bi Liye;Chen Yiqing;Luo Nina;Zhong Xiao(Jiangxi Provincial Fifth People's Hospital,Nanchang,Jiangxi 330000,China)
出处
《首都食品与医药》
2023年第16期154-156,共3页
Capital Food Medicine
关键词
脂代谢紊乱
非典型抗精神病药物
荷叶茶
血脂水平
安全性
Disorder of lipid metabolism
Atypical antipsychotic drugs
Lotus leaf tea
Blood lipid levels
security
