摘要
饲料在动物生长和健康中扮演着重要的角色,然而决定饲料表现的内在机一直是一个所谓的“黑箱”。直到近年来,研究证明营养素能够作为信号分子被细胞和机体感知,并在调控基因表达和代谢活动中起着至关重要的作用。多条分别感知不同营养素的信号通路被发现,营养感知信号调节也已在临床医学中被广泛用于药物开发与疾病控制。然而,在陆生和水产养殖动物中,对主要营养素(蛋白质、糖脂等)的营养感知和代谢调控的研究仍处于起步阶段。因此,我们针对未来在动物营养学中开展营养感知研究可能的研究主题和应用场景提出设想和建议。
Feeding is vital for animal growth and the maintenance of health.However,the underlying mechanisms that mediate dietary performance have long been a so-called black box.It is only during recent years that studies have demonstrated that nutrients act as signals that can be sensed by cells and organisms and that play vital roles in gene expression and metabolism.Multiple signaling pathways have been identified as being responsible for the sensing of discrete nutrients.While successes have been achieved in the exploitation of nutrient-sensing signals in drug discovery and disease control,applications based on the sensing and metabolic control of major nutrients(proteins,lipids,carbohydrates,etc.)in landfarmed animals and aquaculture remain in their infancy.We thus provide a tentative perspective on future research topics and applications of nutrient sensing in animal nutrition.
作者
高宗宇
刘成栋
麦康森
何艮
Zongyu Gao;Chengdong Liu;Kangsen Mai;Gen He(Key Laboratory of Mariculture(Ministry of Education of the People’s Republic of China),Ocean University of China,Qingdao 266003,China;Key Laboratory of Aquaculture Nutrition(Ministry of Agriculture and Rural Affairs),Ocean University of China,Qingdao 266003,China;Laboratory for Marine Fisheries Science and Food Production Processes,Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,China)
出处
《Engineering》
SCIE
EI
CAS
CSCD
2023年第4期112-117,M0006,共7页
工程（英文）
基金
the financial support provided by the National Key Research and Development(R&D)Program of China(2018YFD0900400 to Gen He)
Aoshan Talents Cultivation Program supported by Qingdao National Laboratory for Marine Science and Technology(2017ASTCP-OS12 to Gen He)
Key R&D Program in Shandong Province(2020ZLYS03 to Kangsen Mai)
China Agriculture Research System(CARS-47-G10 to Kangsen Mai).
