摘要
目的探讨一氧化碳(CO)中毒后癫痫发作的危险因素。方法收集2015年1月至2023年1月达州市中心医院收治的CO中毒患者的临床资料,包括性别、年龄、吸烟史、饮酒史、抑郁症史、高血压史、糖尿病史、冠心病史、慢性肾病史、脑卒中病史及慢性阻塞性肺疾病史等资料,通过门诊随访和电话随访方式了解患者的痫性发作情况,分为CO中毒后有癫痫发作组与CO中毒后无癫痫发作组,并按年龄和文化程度进行了分层分析,用logistic回归分析CO中毒后癫痫发作的独立危险因素。结果CO中毒患者共845例,其中有癫痫发作组28例,无癫痫发作组817例。单因素分析显示,有癫痫发作组与无癫痫发作组在年龄、文化程度、高血压史、糖尿病史、脑卒中史、冠心病史及抑郁症史方面比较,差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示,年龄40~59岁[OR=1.27,95%CI(1.141~1.982)]、60~100岁[OR=1.79,95%CI(1.773~2.761)]、脑卒中史[OR=1.72,95%CI(1.549~1.926)]、抑郁症史[OR=4.05,95%CI(3.143~5.587)]及文化程度低是CO中毒后癫痫发作的危险因素,差异有统计学意义(P<0.05)。结论抑郁症、年龄、文化程度及脑卒中与CO中毒患者的癫痫发作存在相关性。
Objective To explore the risk factors of seizure after carbon monoxide(CO)poisoning.Methods Clinical data of patients with CO poisoning admitted to Dazhou Central Hospital from January 2015 to January 2023 were collected,including gender,age,smoking history,drinking history,depression history,hypertension history,diabetes history,history of coronary heart disease,history of chronic kidney disease,stroke history,and history of chronic obstructive pulmonary disease,etc..The patients's seizure information were collected through outpatient follow-up and telephone follow-up.The patients after CO poisoning were divided into a group with seizure and a group without seizure.Stratified analysis was performed according to age and education level.Logistic regression was conducted to analyze independent risk factors of seizure after CO poisoning.Results There were 845 patients with CO poisoning.The group with seizure had 28 patients,and the group without seizure had 817 patients.Univariate analysis showed there were statistically significant differences in age,education level,hypertension history,diabetes history,stroke history,coronary heart disease history,and depression history between two groups(P<0.05).Multivariate logistic regression analysis showed that age at 40~59 years old[OR=1.27,95%CI(1.141~1.982)],age at 60~100 years old[OR=1.79,95%CI(1.773~2.761)],stroke history[OR=1.72,95%CI(1.549~1.926)],depression history[OR=4.05,95%CI(3.143~5.587)],and low education level were risk factors for seizure after CO poisoning,with statistically significant differences(P<0.05).Conclusion Depression,age,educational level,and stroke are related to seizure after CO poisoning.
作者
王亚萌
潘凉泽
陈浪
吕振
姚巧
黄华
WANG Yameng;PAN Liangze;CHEN Lang(Academy of Medicine and Life Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu(610075),Sichuan,China)
出处
《癫痫与神经电生理学杂志》
2023年第4期220-224,共5页
Journal of Epileptology and Electroneurophysiology(China)
基金
四川省达州市科学技术局项目(20YYJC0008)。
