摘要
目的:研究少腹逐瘀丸联合扶阳罐治疗月经不调寒凝血瘀证的临床疗效。方法:将90例月经不调寒凝血瘀证患者随机分为治疗组、对照1组、对照2组,每组各30例。对照1组采用少腹逐瘀丸治疗,对照2组采用扶阳罐治疗,治疗组采用少腹逐瘀丸联合扶阳罐治疗,3组均治疗3个月经周期。比较3组治疗前后中医证候积分,血清性激素[促卵泡刺激素(FSH)、黄体生成素(LH)、催乳素(PRL)、雌二醇(E_(2))、孕酮(P)]及血液流变学指标(全血高、中、低切黏度及血浆黏度水平),评价临床疗效,并比较3组不良反应发生情况。结果:对照1组脱落3例,对照2组脱落2例。总有效率治疗组为93.33%(28/30),对照1组为88.89%(24/27),对照2组为82.14%(23/28),治疗组与对照1、2组比较,差异均有统计学意义(P<0.05);治疗后治疗组中医证候积分、血清性激素指标及血液流变学指标水平均优于对照1组,小腹刺痛、痛经、舌脉积分,血清性激素指标及血液流变学指标水平均优于对照2组,差异均有统计学意义(P<0.01或P<0.05);治疗后对照1组痛经、舌脉积分,FSH、LH、P、E_(2)含量,血液流变学指标改善程度均优于对照2组(P<0.01或P<0.05)。不良反应发生率治疗组为3.33%(1/30),对照1组为7.41%(2/27),对照2组为0,3组比较,差异无统计学意义(P>0.05)。结论:少腹逐瘀丸联合扶阳罐治疗月经不调寒凝血瘀证疗效较佳,可促进月经恢复正常,调节性激素水平,改善血液流变状态。
Objective:To investigate the clinical effect of Shaofu Zhuyu pills combined with Yang-strengthening cupping therapy in the treatment of irregular menstruation with syndrome of cold congelation and blood stasis.Methods:A total of 90 patients with irregular menstruation with syndrome of cold congelation and blood stasis were randomly divided into treatment group,control group 1,and control group 2,with 30 patients in each group.The patients in control group 1 were given Shaofu Zhuyu pills,those in control group 2 were given Yang-strengthening cupping therapy,and those in the treatment group were given Shaofu Zhuyu pills combined with Yang-strengthening cupping therapy;all three groups were treated for three menstrual cycles.The three groups were compared in terms of traditional Chinese medicine(TCM) syndrome score,serum sex hormones [follicle-stimulating hormone(FSH),luteinizing hormone(LH),prolactin(PRL),estradiol(E_(2)),and progesterone(P)],and hemorheological indices(high-,middle-,and low-shear whole blood viscosity and plasma viscosity) before and after treatment;clinical outcome was evaluated,and the incidence rate of adverse reactions was compared between the three groups.Results:Three patients in control group 1 and 2 patients in control group 2 were lost to follow-up.The overall response rate was 93.33%(28/30) in the treatment group,88.89%(24/27) in control group 1,and 82.14%(23/28) in control group 2,with a significant difference between the treatment group and control groups 1 and 2(P<0.05).After treatment,the treatment group had significantly better TCM syndrome score,serum sex hormones,and hemorheological indices than control group 1,as well as significantly better scores of stabbing pain in the lower abdomen,dysmenorrhea,and tongue veins,serum sex hormones,and hemorheological indices than control group 2(P<0.01 or P<0.05).Compared with control group 2 after treatment,control group 1 had significantly better improvements in the scores of dysmenorrhea and tongue veins,the content of FSH,LH,P,and E_2,and
作者
王聪聪
张晨晨
郭舟
李铁浪
唐雨兰
WANG Congcong;ZHANG Chenchen;GUO Zhou;LI Tielang;TANG Yulan(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China)
出处
《湖南中医杂志》
2023年第6期14-18,共5页
Hunan Journal of Traditional Chinese Medicine
基金
湖南省大学生创新创业训练计划一般项目(S202210541025)。
关键词
月经不调
寒凝血瘀证
少腹逐瘀丸
扶阳罐
irregular menstruation
syndrome of cold congelation and blood stasis
Shaofu Zhuyu pills
Yang-strengthening cupping therapy
