摘要
目的 研究非静脉曲张性上消化道出血患者采用奥曲肽、艾司奥美拉唑联合治疗的临床效果及安全性。方法 方便抽取2018年1月—2022年7月邳州市中医院接诊治疗非静脉曲张性上消化道出血患者82例为研究对象,根据红蓝小球抽签结果分作观察组(红色小球,41例)与对照组(蓝色小球,41例),其中对照组采用艾司奥美拉唑治疗;观察组采用双药艾司奥美拉唑、奥曲肽联合指标。比较两组治疗总有效率、止血时间、住院时间、血红蛋白和尿素氮水平,统计不良反应发生及再出血率。结果 观察组总有效率高于对照组,差异有统计学意义(P<0.05)。观察组止血时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组血红蛋白水平比较,差异无统计学意义(P>0.05),观察组尿素氮水平优于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组患者发生再出血为0低于对照组的17.07%,差异有统计学意义(χ^(2)=5.623,P<0.05)。结论 非静脉曲张性上消化道出血患者通过奥曲肽、艾司奥美拉唑联合用药治疗可帮助患者快速止血,调节胃酸失衡问题,同时降低再出血发生率。
Objective To study the clinical effect and safety of combined treatment of octreotide and esomeprazole in patients with non-variceal upper gastrointestinal bleeding.Methods 82 patients with non-variceal upper gastrointestinal bleeding who were treated in Pizhou Hospital of Traditional Chinese Medicine from January 2018 to July 2022 were conveniently selected as the research subjects.According to the results of the red and blue ball draw,they were divided into the observation group(red ball,41 cases)and the control group(blue ball,41 cases).The control group was treated with esomeprazole;the observation group used a combination of dual drug Esomeprazole and octreotide as indicators.Compared the total effective rate,hemostatic time,hospital stay,hemoglobin and urea nitrogen levels between the two groups,and calculate the incidence of adverse reactions and rebleeding rates.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The observation group had shorter hemostasis time and hospitalization time than the control group,and the difference was statistically significant(P<0.05).After treatment,there was no statistically significant difference in hemoglobin levels between the two groups(P>0.05).The urea nitrogen levels in the observation group were better than those in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The incidence of rebleeding in the observation group was 0 lower than that in the control group(17.07%),and the difference was statistically significant(χ^(2)=5.623,P<0.05).Conclusion The combined treatment of octreotide and esomeprazole in patients with non-variceal upper gastrointestinal bleeding can help patients quickly stop bleeding,regulate gastric acid imbalance,and reduce rebleeding.It is worth advocating the use of promotion.
作者
张晓
王红贵
曲悦
ZHANG Xiao;WANG Honggui;QU Yue(Department of Gastroenterology,Pizhou Hospital of Traditional Chinese Medicine,Pizhou,Jiangsu Province,221300 China)
出处
《中外医疗》
2023年第20期122-125,共4页
China & Foreign Medical Treatment
