摘要
目的:探讨脑小血管病(cerebral small vascular disease,CSVD)合并睡眠障碍患者应用重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)联合醒脑开窍汤治疗的效果及对血清5-羟色胺(5-hydroxytryptamine,5-HT)、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)和神经元特异性烯醇化酶(neuron specific enolase,NSE)水平的影响。方法:选取2019年7月-2022年7月于连南瑶族自治县人民医院就诊的106例CSVD合并睡眠障碍患者为研究对象,依据随机数表法将其分为对照组与研究组,各53例。对照组接受醒脑开窍汤治疗,研究组基于对照组基础上联合rTMS治疗,两组患者疗程均为2周。比较两组疗效及治疗前后匹茨堡睡眠质量指数量表(Pittsburgh sleep quality index,PSQI)评分、血清5-HT、BDNF、NSE水平。结果:研究组治疗总有效率为94.34%,明显高于对照组的79.25%,差异有统计学意义(P<0.05)。治疗前,两组PSQI评分比较,差异无统计学意义(P>0.05);治疗后,两组PSQI评分明显低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组5-HT、BDNF、NSE水平比较,差异无统计学意义(P>0.05);治疗后,两组5-HT、BDNF水平明显高于治疗前,NSE水平明显低于治疗前,且研究组5-HT、BDNF水平明显高于对照组,NSE水平明显低于对照组,差异有统计学意义(P<0.05)。结论:CSVD合并睡眠障碍患者应用r TMS联合醒脑开窍汤治疗效果显著,同时能有效改善血清5-HT、BDNF和NSE水平。
Objective:To investigate the effect of repetitive transcranial magnetic stimulation(rTMS)combined with Xingnao Kaiqiao Decoction in the treatment of cerebral small vascular disease(CSVD)complicated with sleep disorder and its influence on the serum levels of 5-hydroxytryptamine(5-HT),brain-derived neurotrophic factor(BDNF)and neuron specific enolase(NSE)levels.Method:A total of 106 CSVD patients with sleep disorder treated in Liannan Yao Autonomous County People's Hospital from July 2019 to July 2022 were selected as the research objects.According to random number table method,they were divided into control group and study group,with 53 cases in each group.The control group received Xingnao Kaiqiao Decoction,and the study group received rTMS based on the control group,the treatment course of both groups was 2 weeks.The clinical efficacy and Pittsburgh sleep quality index(PSQI)score,serum 5-HT,BDNF,NSE levels before and after treatment were compared between the two groups.Result:The total effective rate of the study group was 94.34%,which was significantly higher than 79.25%of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in PSQI scores between the two groups(P>0.05);after treatment,the PSQI scores of the two groups were significantly lower than those before treatment,that in the study group was lower than that in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of 5-HT,BDNF and NSE between the two groups(P>0.05);after treatment,the levels of 5-HT and BDNF in two groups were significantly higher than those before treatment,and the levels of NSE were significantly lower than those before treatment,and the levels of 5-HT and BDNF in the study group were significantly higher than those in the control group,and the levels of NSE was significantly lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion:
作者
周礼
陈世姣
张明兴
石艺华
危智盛
ZHOU Li;CHEN Shijiao;ZHANG Mingxing;SHI Yihua;WEI Zhisheng(The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou 510062,China;不详)
出处
《中外医学研究》
2023年第24期148-151,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
清远市科技计划项目(2021SJXM026)。
关键词
脑小血管病
睡眠障碍
醒脑开窍汤
5-羟色胺
脑源性神经营养因子
神经元特异性烯醇化酶
Cerebral small vascular disease
Sleep disorder
Xingnao Kaiqiao Decoction
5-hydroxytryptamine
Brainderived neurotrophic factor
Neuron specific enolase
