摘要
目的:探讨中药坤康粉治疗宫颈持续性高危型人乳头瘤病毒(HR-HPV)感染的临床疗效。方法:选择2019年7月至2021年6月于该院治疗的宫颈持续性HR-HPV感染患者114例,采用简单随机分组法分为对照组和观察组,各57例。对照组患者给予常规西医治疗,观察组患者在对照组基础上予以中药坤康粉治疗,共治疗4个月经周期。两组患者治疗前后均进行宫颈分泌物HR-HPV和液基薄层细胞学(TCT)检查、中医证候评估、阴道菌群状况及免疫指标[T淋巴细胞亚群CD3^(+)、CD4^(+),免疫细胞调节因子白细胞介素(IL)2、IL-6]检测,记录其治疗期间不良反应发生情况。两组患者均随访1年,统计1年复发率。结果:观察组患者的临床治疗总有效率为87.72%(50/57),高于对照组的71.93%(41/57),差异有统计学意义(P<0.05)。治疗后,两组患者的TCT结果正常率高于治疗前,且观察组患者高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者的中医证候积分均低于治疗前,且观察组患者低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者的阴道分泌物pH及革兰染色Nugent评分明显降低(P<0.05);且观察组患者阴道分泌物pH及革兰染色Nugent评分均低于对照组(P<0.05),阴道菌群恢复率高于对照组(P<0.05),上述差异均有统计学意义。治疗后,两组患者的CD3^(+)、CD4^(+)和IL-2水平均高于治疗前(P<0.05),IL-6水平均低于治疗前(P<0.05);且观察组患者的CD3^(+)、CD4^(+)和IL-2水平均高于对照组(P<0.05),IL-6水平低于对照组(P<0.05),上述差异均有统计学意义。观察组与对照组患者的不良反应发生率、1年复发率比较,差异均无统计学意义(P>0.05)。结论:中药坤康粉能够调节宫颈持续性HR-HPV感染患者的免疫功能,提高HR-HPV转阴率,减轻中医证候,且临床疗效及安全性均较佳。
OBJECTIVE:To probe into the clinical efficacy of Kunkang powder in the treatment of cervical persistent high-risk human papilloma virus(HR-HPV)infection.METHODS:A totao of 114 patients with cervical persistent HR-HPV admitted into this hospital from Jul.2019 to Jun.2021 were selected to be divided into the control group and observation group via simple randomized block,with 57 cases in each group.The control group was given conventional western treatment,while the observation group received Kunkang powder on the basis of the control group,both groups were treated for 4 menstrual cycles.Patients in both groups were underwent HR-HPV and liquid-based thin-layer cytology(TCT)examination of cervical secretions,TCM syndrome assessment,vaginal flora status and immune indicators detection[T-lymphocyte subpopulations CD3^(+)and CD4^(+),immune cell regulators interleukin(IL)2 and IL-6]before and after treatment,the incidence of adverse drug reactions during treatment was recorded.Both groups were followed up for 1 year,and the 1-year relapse rate was counted.RESULTS:The clinical total effective rate of the observation group was 87.72%(50/57),higher than that of the control group(71.93%,41/57),with statistically significant difference(P<0.05).After treatment,the normal rate of TCT results of both groups was higher than that before treatment,and that of the observation group was higher than the control group,with statistically significant difference(P<0.05).After treatment,the TCM syndrome integral of both groups were lower than that before treatment,and that of the observation group was lower than the control group,with statistically significant difference(P<0.05).After treatment,the pH value of vaginal secretions and nugent Gram staining score decreased significantly in both groups(P<0.05);the pH value of vaginal secretions and nugent Gram staining score in the observation group were lower than those in the control group(P<0.05),and the recovery rate of vaginal flora of the observation group was higher than those of the co
作者
姬晓丽
张桂平
司晴
陈葆芳
王桂华
JI Xiaoli;ZHANG Guiping;SI Qing;CHEN Baofang;WANG Guihua(Dept.of Gynecology,Hengshui Hospital of Traditional Chinese Medicine,Hebei Hengshui 053000,China)
出处
《中国医院用药评价与分析》
2023年第8期971-974,979,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
河北省中医药管理局科研计划项目(No.2022279)。
关键词
人乳头瘤病毒
高危型
坤康粉
液基薄层细胞学
Human papilloma virus
High risk type
Kunkang powder
Liquid-based thin layer cytology
