摘要
目的分析放射治疗(简称放疗)对儿童高危神经母细胞瘤(NB)预后的影响。方法回顾性分析100例高危NB患儿的临床资料。通过单因素分析筛选NB患儿复发和生存的影响因素,随访放疗组与未放疗组NB患儿的无复发生存期和总生存期,采用Kaplan-Meier法进行生存分析,采用Log-rank检验比较放疗组与未放疗组无复发生存率和总生存率的差异。结果100例NB患儿中,复发34例,未复发66例,生存74例,死亡26例。单因素分析结果显示,年龄、肿瘤远处转移、放疗是NB患儿肿瘤复发的影响因素(P<0.05),年龄、肿瘤远处转移、MYCN基因扩增是NB患儿生存情况的影响因素(P<0.05)。生存分析结果显示,放疗组与未放疗组NB患儿的无复发生存率比较差异有统计学意义(P<0.05),但2组NB患儿的总生存率比较差异无统计学意义(P>0.05)。结论年龄、肿瘤远处转移、放疗是NB复发的影响因素,年龄、肿瘤远处转移、MYCN基因扩增是NB患儿生存情况的影响因素。放疗能显著提升高危NB患儿的无复发生存率,但不能显著提升总生存率。
Objective To analyze the effect of radiotherapy on the prognosis of pediatric high-risk neuroblastoma(NB).Methods The clinical data of 100 cases of high-risk NB were retrospectively analyzed.The influencing factors affecting NB recurrence and survival were assessed through single factor analysis.The recurrence-free survival and overall survival of NB in radiotherapy group and non-radiotherapy group were analyzed by Kaplan-Meier method.The recurrence-free survival rate and overall survival rate of NB were compared by Log-rank.Results Of 100 children with NB,34 recurred,66 did not relapse,74 survived,and 26 died.Univariate analysis showed that age,distant tumor metastasis and radiotherapy were influencing factors of tumor recurrence in NB children(P<0.05),while age,distant tumor metastasis,and MYCN gene amplification were influencing factors of survival of NB children(P<0.05).The results of survival analysis showed that there was statistically significant difference in relapse-free survival rate between the radiotherapy group and the non-radiotherapy group(P<0.05),but there was no statistically significant difference in overall survival rate between the two groups(P>0.05).Conclusion Age,distant tumor metastasis,and radiotherapy are risk factors for NB recurrence,while age,distant tumor metastasis,and MYCN gene amplification are influencing factors for NB survival.Radiotherapy can improve the recurrence-free survival rate of children with high-risk NB,but it has no significant effect on the overall survival rate.
作者
朱世春
唐汝泽
ZHU Shichun;TANG Ruze(Department of Pediatric Surgery,the Affiliated Hospital of Yangzhou University,Yangzhou,Jiangsu,225000;Department of General Surgery,the Affiliated Children′s Hospital of Soochow University,Suzhou,Jiangsu,215000)
出处
《实用临床医药杂志》
2023年第13期16-19,25,共5页
Journal of Clinical Medicine in Practice
基金
江苏省重点研发计划(社会发展)项目(BE2020659)。
关键词
神经母细胞瘤
放射治疗
无复发生存率
总生存率
预后
远处转移
neuroblastoma
radiotherapy
recurrence-free survival rate
overall survival rate
prognosis
distant metastasis
