摘要
目的比较2017年河南省原水源性高碘地区和2019年新划定水源性高碘地区未加碘食盐覆盖情况、儿童碘营养和甲状腺肿大率变化趋势。方法采用横断面调查方法,2017年对河南省20个原高碘县(市、区)全部进行居民户食用盐监测,并从中选取10个县(市、区)开展水碘、8~10岁儿童尿碘和甲状腺容积监测,共采集盐样4430份、尿样1012份,测量1012名儿童甲状腺容积。2019年对新划定的55个含有高碘行政村的县(市、区)全部开展居民户食用盐、水碘、8~10岁儿童尿碘和甲状腺容积监测,共采集盐样9835份、尿样9830份,测量8896名儿童甲状腺容积。对两年的监测结果进行比较,并采用单因素logistic回归分析儿童尿碘和甲状腺肿大率之间的关系。结果2019年新划定高碘地区的水碘含量较2017年原高碘地区明显下降(119.8比191.0μg/L),差异有统计学意义(Z=-2.48,P=0.013)。2019年未加碘食盐率仅为35.5%(3494/9835),显著低于2017年的未加碘食盐率(96.2%,4263/4430,χ^(2)=4536.74,P<0.001)。2017和2019年儿童尿碘中位数分别为338.2和317.8μg/L,二者比较差异有统计学意义(Z=-2.46,P=0.014)。2017和2019年儿童甲状腺肿大率分别为1.5%(15/1012)和2.1%(187/8896),二者比较差异无统计学意义(χ^(2)=1.76,P=0.185)。单因素logistic回归分析结果显示,以尿碘<100μg/L组为对照组,随着尿碘水平的增高(100~199、200~299、≥300μg/L组),甲状腺肿大风险增加(但肿大率均未超过5%),差异均有统计学意义[比值比(OR)=8.64、7.68、10.69,均P<0.05]。结论实施新的水源性高碘地区划定标准后,河南省未加碘食盐供应相对滞后,儿童碘营养水平仍然偏高,但甲状腺肿大率较稳定。
Objective To compare the coverage rate of non-iodized salts,children's iodine nutrition and the change trend of goiter rate between the original water source high iodine areas in Henan Province in 2017 and the newly designated water source high iodine areas in 2019.Methods Using a cross-sectional survey method,household edible salt monitoring was conducted in all 20 counties(cities,districts)with high iodine content in Henan Province in 2017.Ten counties(cities,districts)were selected to monitor water iodine,urinary iodine and thyroid volume of children aged 8 to 10 years.A total of 4430 salt samples and 1012 urine samples were collected,and thyroid volume of 1012 children were measured.In 2019,monitoring of household edible salt,water iodine,urinary iodine,and thyroid volume was carried out in all 55 newly designated counties(cities,districts)with high iodine village.A total of 9835 salt samples and 9830 urine samples were collected,and the thyroid volume of 8896 children was measured.The monitoring results of two years were compared,and the relationship between children's urinary iodine and goiter rate was analyzed by univariate logistic regression.Results In 2019,the water iodine content in newly designated high iodine areas decreased compared to the original high iodine areas in 2017(119.8 to 191.0μg/L),and the difference was statistically significant(Z=-2.48,P=0.013).The rate of noniodized salts in 2019 was only 35.5%(3494/9835),significantly lower than that in 2017(96.2%,4263/4430,x^(2)=4536.74,P<0.001).The median urinary iodine of children in 2017 and 2019 were 338.2 and 317.8μg/L,respectively,the difference between the two years was statistically significant(Z=-2.46,P=0.014).In 2017 and 2019,the goiter rate of children aged 8 to 10 years was 1.5%(15/1012)and 2.1%(187/8896),respectively,and there was no significant difference between the two years(x^(2)=1.76,P=0.185).The results of univariate logistic regression analysis showed that,compared with the control group with urinary iodine<100μg/L,the risk of
作者
杨金
滕妍利
衡婧雅
朱琳
李小烽
郑合明
张莉
孙宁
陈玕
Yang Jin;Teng Yanli;Heng Jingya;Zhu Lin;Li Xiaofeng;Zheng Heming;Zhang Li;Sun Ning;Chen Gan(Department of Endemic Disease,Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450016,China)
出处
《中华地方病学杂志》
CAS
北大核心
2023年第6期477-482,共6页
Chinese Journal of Endemiology
基金
河南省医学科技攻关计划(LHGJ20200122、LHGJ20210146)。
关键词
碘
水
尿
盐类
甲状腺肿
标准
Iodine
Water
Urine
Salts
Goiter
Criterion
