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浓缩生长因子用于年轻恒牙根尖周炎再生性牙髓治疗2例及文献复习

Application of concentrated growth factor in regenerative endodontic treatment of immature permanent tooth with periapical periodontitis:Two cases and literature review
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摘要 浓缩生长因子(CGF)是一种血小板浓缩物,是利用血液样本和特殊的离心设备制备而成的含有高浓度生长因子的纤维蛋白团块,具有较好的可塑性和促再生能力。其中,生长因子可作为良好的支架基质,能够将未分化的间充质细胞吸引到相应部位,促进血管生成和细胞增殖;而纤维蛋白形成的三维网状结构,则使得生长因子、白细胞和成纤维细胞等更易附着于蛋白表面,为细胞的增殖分化提供基质,最终促进牙髓组织修复。 Concentrated growth factor(CGF)is a kind of platelet concentrate,which is a fibrin block rich in growth factors.CGF is prepared by blood samples with special centrifugal equipment,and has good plasticity and regeneration promotion ability.Growth factor can be used as a good scaffold matrix,which can attract undifferentiated mesenchymal cells to the corresponding sites,promoting angiogenesis and cell proliferation.Fibrin with three-dimensional reticular structure can improve the adherence of growth factors,white blood cells and fibroblasts to the protein surface,provide a matrix for cell proliferation and differentiation,and ultimately promote the repair of pulp tissue.
作者 王军辉 胡颖 刘芳 王飞 陈宇江 王小竞 Junhui Wang;Ying Hu;Fang Liu;Fei Wang;Yujiang Chen;Xiaojing Wang(State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Disease&Shaanxi Clinical Research Center for Oral Diseases,Stomatology Department of Children,School of Stomatology,The Fourth Military Medical University,Xi′an 710032,China)
出处 《中华口腔医学研究杂志(电子版)》 CAS 2023年第2期81-88,共8页 Chinese Journal of Stomatological Research(Electronic Edition)
基金 国家口腔疾病临床医学研究中心专项课题(LCA202010) 国家自然科学基金(青年项目,82100954) 陕西省重点研发计划项目(2022KW-12) 军事口腔医学国家重点实验室自主研究课题(2019ZA06)。
关键词 浓缩生长因子 年轻恒牙 根尖周炎 再生性牙髓治疗 Concentrated growth factor Immature permanent teeth Periapical periodontitis Regenerative endodontic therapy
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