摘要
根管治疗是处理牙髓根尖周病的常规方法,其中根管封药是感染根管治疗过程中的重要步骤,通过将根管消毒药物充填于根管内,起到抑菌、促进修复和防止再感染的作用。目前,临床常用于根管封药的氢氧化钙、氯己定及抗生素制剂难以达到有效性及安全性的理想预期。近年来,分子生物学和纳米科技的进步推动了以抗菌肽、纳米颗粒为代表的新型抗菌药物的发展。本文对目前临床根管封药的常用药物及研究进展加以总结,并讨论根管药物消毒的发展趋势。
Root canal therapy is a conventional treatment for pulpal and periapical diseases.Intracanal interappointment medicaments are important in treatment of pulpal necrosis and apical periodontitis.In addition to killing microorganisms,intracanal medicaments may promote tissue healing and prevent reinfection.The most commonly used intracanal medicaments are calcium hydroxide,chlorhexidine digluconate,and triple antibiotic paste,which can not offer excellent efficacy and safety.The progress of molecular biology and nanotechnology has promoted the development of new antibacterial drugs represented by antimicrobial peptides and nanoparticles.The present article introduces the common used intracanal medicaments in endodontics,and the progress of developing novel medicaments.The development trend of intracanal medicaments in endodontics is also discussed.
作者
刘红艳
韦曦
凌均棨
Liu Hongyan;Wei Xi;Ling Junqi(Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510055,China)
出处
《中华口腔医学研究杂志（电子版）》
CAS
2023年第2期69-74,共6页
Chinese Journal of Stomatological Research(Electronic Edition)
基金
广东省财政高水平医院建设专项资金(174⁃2018⁃XMZC⁃0001⁃03⁃0125/D⁃08)
广州市临床重大技术项目(2023P⁃ZD07)。
关键词
根管封药
根管治疗
氢氧化钙
抗菌肽
纳米颗粒
Intracanal medicaments
Root canal therapy
Calcium hydroxide
Antimicrobial peptides
Nanoparticles
