摘要
Perfluorinated or polyfluorinated compounds(PFCs)continue entering to the environmental as individuals or mixtures,but their toxicological information remains largely unknown.Here,we investigated the toxic effects and ecological risks of Perfluorooctane sulfonic acid(PFOS)and its substitutes on prokaryotes(Chlorella vulgaris)and eukaryotes(Microcystis aeruginosa).Based on the calculated EC50 values,the results showed that PFOS was significantly more toxic to both algae than its alternatives including Perfluorobutane sulfonic acid(PFBS)and 6:2 Fluoromodulated sulfonates(6:2 FTS),and the PFOS-PFBS mixture was more toxic to both algae than the other two PFC mixtures.The action mode of binary PFC mixtures on Chlorella vulgaris was mainly shown as antagonistic and on Microcystis aeruginosa as synergistic,by using Combination index(CI)model coupled with Monte Carlo simulation.The mean risk quotient(RQ)value of three individual PFCs and their mixtures were all below the threshold of 10^(−1),but the risk of those binary mixtures were higher than that of PFCs individually because of their synergistic effect.Our findings contribute to enhance the understanding of the toxicological information and ecological risks of emerging PFCs and provide a scientific basis for their pollution control.
基金
supported by the National Key Research and Development Program of China(No.2018YFC1407501)
the Key Laboratory Open Fund of Fishery Ecology Environment,Ministry of Agriculture,China.
