摘要
目的探讨银丹心脑通软胶囊联合丁苯酞治疗中风的效果。方法抽取河南省第二人民医院2020年1月至2022年1月收治的中风患者107例,按随机数字表法分为对照组(54例)与研究组(53例)。对照组接受常规西药、丁苯酞治疗,研究组在对照组基础上接受银丹心脑通软胶囊治疗,两组均治疗2周。记录并分析两组患者治疗前及治疗2周后中医证候评分、美国国立卫生院卒中量表(NIHSS)评分、Barthel指数(BI)及凝血功能指标,观察两组治疗期间不良反应发生率。结果试验过程中,研究组剔除2例患者,对照组剔除3例患者,研究组、对照组最终各纳入51例患者。两组发病至入院时间、合并症等资料比较,差异未见统计学意义(P>0.05)。治疗2周后,两组中医证候评分均较治疗前降低,且研究组低于对照组(P<0.05);两组NIHSS评分均较治疗前降低,BI均较治疗前升高,且研究组变化更为显著(P<0.05);两组纤维蛋白原、纤溶酶原活性均较治疗前降低,且研究组低于对照组(P<0.05)。研究组不良反应总发生率为9.80%(5/51),对照组为5.88%(3/51),差异未见统计学意义(P>0.05)。结论银丹心脑通软胶囊联合丁苯酞治疗在改善中风患者临床症状、凝血功能、神经功能及日常生活能力方面效果显著。
Objective To investigate the therapeutic effect of Yindan Xinnaotong soft capsule combined with butylphthalide on stroke.Methods A total of 107 stroke patients treated in Henan Second Provincial People’s Hospital from January 2020 to January 2022 were selected.They were divided into control group(54 cases)and study group(53 cases)by random number table method.The control group was treated with conventional western medicine and butylphthalide,while the study group was treated with Yindan Xinnaotong soft capsule based on the treatment of the control group.Both groups were treated for 2 weeks.The preoperative and postoperative traditional Chinese medicine syndrome scores,National Institutes of Health stroke scale(NIHSS)scores,Barthel Index(BI)and coagulation function indexes of the two groups were recorded and analyzed.And the incidence of adverse reactions during treatment of the two groups were observed.Results During the study,2 patients were excluded from the study group,3 patients were excluded from the control group,and 51 patients were included in each of the two groups,finally.There was no statistical significant difference between the two groups in time from onset to admission and comorbidity(P>0.05).After 2 weeks of treatment,the traditional Chinese medicine syndrome scores of the two groups were lower than those before treatment,and the study group had lower traditional Chinese medicine syndrome score,compared with the control group(P<0.05).After 2 weeks of treatment,the NIHSS scores of the two groups were significantly decreased,and the BI of the two groups were significantly increased,compared with those before treatment,and the changes in the study group were more significant than those in the control group(P<0.05).After 2 weeks of treatment,the fibrinogen and plasminogen activities in the two groups were lower than those before treatment,and decrease in the study group was more significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the study group(9.8%,
作者
孙晓
Sun Xiao(Department of Neurology,Henan Second Provincial People's Hospital,Xinzheng 451191,China)
出处
《中国实用医刊》
2023年第6期120-122,F0003,共4页
Chinese Journal of Practical Medicine
关键词
中风
银丹心脑通软胶囊
丁苯酞
神经功能
凝血功能
Stroke
Yindan Xinnaotong soft capsule
Butylphthalide
Neurological function
Coagulation function
