摘要
目的研究血清干扰素-γ(IFN-γ)、白细胞介素-17(IL-17)水平与大叶性肺炎患儿病情程度及预后的相关性。方法采用前瞻性对照研究,抽取2020年8月至2022年8月南阳市第一人民医院收治的82例大叶性肺炎患儿作为研究对象,根据临床肺部感染评分(CPIS)将患儿分为轻度组(CPIS<7分,40例)和重度组(CPIS≥7分,42例)。另抽取同期于医院行健康体检的41例儿童为对照组。比较三组儿童血清中IFN-γ、IL-17、C-反应蛋白(CRP)水平及中性粒细胞百分比,并绘制受试者工作特征曲线分析血清IFN-γ、IL-17水平及二者联合对大叶性肺炎患儿预后的预测价值。结果对照组血清IFN-γ、IL-17水平低于轻度组和重度组,且轻度组低于重度组,差异有统计学意义(P<0.05);对照组CRP、中性粒细胞百分比低于轻度组和重度组,且轻度组低于重度组,差异有统计学意义(P<0.05)。Pearson直线相关性分析结果显示,血清IFN-γ与CRP、中性粒细胞百分比之间呈正相关性(r>0,P<0.05),血清IL-17与CRP、中性粒细胞百分比之间呈正相关性(r>0,P<0.05)。受试者工作特征曲线分析结果显示,血清IFN-γ联合IL-17预测大叶性肺炎患儿预后的曲线下面积(AUC)为0.854,均大于血清IFN-γ(AUC=0.779)、IL-17(AUC=0.757)单独预测大叶性肺炎的效能,差异有统计学意义(P<0.05)。结论大叶性肺炎患儿血清IFN-γ、IL-17水平会随着病情加重而逐渐升高,且二者联合检测可有效预测大叶性肺炎患儿的预后。
Objective To study the correlation of levels of serum interferon-γ(IFN-γ)and interleukin-17(IL-17)with the severity and prognosis of lobar pneumonia in children.Methods Eighty-two patients with lobar pneumonia admitted to Nanyang First People’s Hospital from August 2020 to August 2022 were selected as the study subjects for the prospective study.According to the clinical pulmonary infection score(CPIS),children were divided into mild group(CPIS<7,40 cases)and severe group(CPIS≥7,42 cases).Another 41 children who underwent physical examination in the hospital during the same period were selected as the control group.The levels of serum of IFN-γ,IL-17,C-reactive protein(CRP),and the percentage of neutrophils were compared among the three groups.Receiver operating characteristic curve was drawn to analyze the predictive value of serum IFN,IL-17 and combination of them for the prognosis of children with lobar pneumonia.Results The serum levels of IFN-γand IL-17 in the control group were lower than those in the mild group and the severe group,and the levels of serum IFN-γand IL-17 in the mild group were lower than those in the severe group,with a statistical significant difference(P<0.05).The CRP level and neutrophil percentage in the control group were lower than those in the mild group and severe group,and these indexes in the mild group were lower than those in the severe group,with a statistical significant difference(P<0.05).Results of Pearson linear correlation analysis showed that serum IFN-γwas positively correlated with CRP and neutrophil percentage(r>0,P<0.05),while serum IL-17 was positively correlated with CRP and neutrophil percentage(r>0,P<0.05).The results of receiver operating characteristic curve analysis showed that the area under the curve(AUC)of serum IFN-γcombined with IL-17 in predicting the prognosis of lobar pneumonia in children was 0.854,which was significantly higher than that of serum IFN-γalone(AUC=0.779)and IL-17 alone(AUC=0.757)in predicting lobar pneumonia(P<0.05).Conclusion
作者
李倩
王有峰
Li Qian;Wang Youfeng(Department of Pediatrics,Nanyang First People's Hospital,Nanyang 473000,China)
出处
《中国实用医刊》
2023年第6期55-58,共4页
Chinese Journal of Practical Medicine
