摘要
动物界中蕴藏着丰富且宝贵的活性肽资源,其中动物蛋白源免疫调节肽具有高安全性、低过敏性、成本低等优势,在人类营养健康和疾病防治中发挥着不可替代的作用。其免疫调节活性作用与氨基酸组成、序列及肽链长度等多种因素有关。近年来,围绕动物蛋白源相关的免疫活性成分及功能研究已取得了较多新的进展,但鲜有团队对其免疫调节肽进行详细介绍并总结。本文综述了近年来动物蛋白源免疫调节肽的构效关系和作用机制,总结了不同动物蛋白来源的免疫调节肽的特点,并对动物蛋白源免疫调节肽的未来研究和发展趋势进行展望,以期为动物蛋白源免疫调节肽的进一步研究与开发提供参考。
Animals have long been a rich and invaluable source of bioactive peptides,of which animal protein-derived immunomodulatory peptides have the advantages of high safety,low allergenicity and low cost,and play an irreplaceable role in human health and disease prevention.The immunomodulatory activities of peptides are related to amino acid composition,sequence and peptide chain length.In recent years,many new advances have been made around the study of immunomodulatory components and bioactivities related to animal protein sources,but few teams have introduced and summarized the immunomodulatory peptides in detail.In this review,the structure-effect relationships and mechanism of action of animal protein-derived immunomodulatory peptides in recent years are reviewed,the characteristics of immunomodulatory peptides from different animal protein sources are summarized,and the future research and development trend of animal protein-derived immunomodulatory peptides are prospected,which might contribute to further research and development of animal protein-derived immunomodulatory peptides.
作者
梁泳仪
王宏
白卫东
肖更生
曾晓房
LIANG Yongyi;WANG Hong;BAI Weidong;XIAO Gengsheng;ZENG Xiaofang(Zhongkai University of Agriculture and Engineering,Guangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology,Key Laboratory of Green Processing and Intelligent Manufacturing of Lingnan Specialty Food,Ministry of Agriculture and Rural Affairs,School of Light Industry and Food Technology,Guangzhou 510225,China)
出处
《食品工业科技》
CAS
北大核心
2023年第18期492-501,共10页
Science and Technology of Food Industry
基金
广东省重点领域研发计划项目(2020B0202080002)
仲恺农业工程学院研究生教育创新计划项目(KA220160241)
广东省岭南特色食品科学与技术重点实验室项目(2021B1212040013)。
关键词
免疫调节肽
动物蛋白
构效关系
分子机制
immunomodulatory peptide
animal protein
structure-effect relationship
molecular mechanisms
