摘要
药物辨别技术是一种研究药物主观刺激效应的行为药理学技术。目前,药物辨别技术已广泛应用于中枢神经系统药物临床前药物研发中,其中最为广泛的是用于药物的精神依赖性评价。该文简要介绍了药物辨别技术的基本原理,初步阐述了药物辨别的主观效应、时程效应、立体特异性和个体差异,以及受体机制等相关特点和应用,并对其在新型精神活性物质致幻剂和大麻类药物方面的应用进行展望。
Drug discrimination is a behavioral pharmacological technique to study the discriminative stimulus effects of drug.Currently drug discrimination has been widely used in preclinical drug development of CNS drugs,the most extensive of which is psychodependent research in the field of drug abuse.This review describes in general the basic principles of drug discrimination,preliminarily elaborates on the relevant characteristics and applications of the subjective effects,time-course effect,stereo specificity,individual differences,and receptor mechanisms,and its development prospects for hallucinogens and cannabis drugs are also presented.
作者
符丹
洪青晓
顾钧
徐泽民
庄丁丁
徐文锦
刘惠芬
周文华
FU Dan;HONG Qing-xiao;GU Jun;XU Ze-min;ZHUANG Ding-ding;XU Wen-jin;LIU Hui-fen;ZHOU Wen-hua(Dept of Academic Research,Ningbo Kangning Hospital,Key Laboratory of Addiction Research of Zhejiang Province,Ningbo Zhejiang 315201,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2023年第9期1623-1627,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 82071499)
浙江省医药卫生科技计划项目(No 2022KY342)
宁波市医学科技计划项目(No 2020Y21)
浙江省医学重点扶植学科建设项目(No 00-F06)。
关键词
药物辨别技术
药物滥用
内隐感受性
辨别刺激
主观效应
致幻剂
大麻素
drug discrimination
drug abuse
interoceptive effects
the stimulus effect of discrimination
subjective effects
hallucinogens
cannabis
