摘要
目的:观察赵文霞教授研制的消脂护肝胶囊对痰湿瘀阻型非酒精性脂肪性肝炎患者肝脂肪变的影响,为临床合理用药提供依据。方法:采用SPSS 25.0统计学软件将72例符合纳入标准的患者根据入组先后顺序随机分为治疗组和对照组,每组36例,采用单盲实施方法。在运动、饮食指导等基础上,治疗组口服院内制剂消脂护肝胶囊,每日3次,每次3粒;对照组口服多烯磷脂酰胆碱胶囊(易善复),每日3次,每次2粒,两组疗程均为3个月。比较两组患者治疗前后肝脏瞬时弹性成像受控衰减参数CAP值、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、高密度脂蛋白(high-density lipoprotein cholesterol,HDLC)、白细胞介素-6(interleukin-6,IL-6)、游离脂肪酸(free fat acid,FFA)及中医证候积分,并比较两组患者中医证候疗效。结果:(1)治疗后,两组患者CAP值均低于治疗前;治疗组CAP值为(248.24±22.80)dB·m^(-1),低于同期对照组(P<0.05)。(2)治疗后,两组患者ALT、AST水平均显著降低;治疗组ALT水平为(36.82±10.46)U·L^(-1),AST水平为(26.87±6.99)U·L^(-1),均低于同期对照组(P<0.05)。(3)治疗后,两组患者TG、TC水平均低于治疗前,HDLC水平显著高于治疗前;治疗组TG水平为[1.21(0.95,1.37)]mmol·L^(-1)、TC水平为(3.53±0.71)mmol·L^(-1),均低于同期对照组,HDLC水平为(1.44±0.23)mmol·L^(-1),高于同期对照组(P<0.05)。(4)治疗后,两组患者血清IL-6、FFA水平均显著低于治疗前;治疗组血清IL-6水平为[1.82(1.64,2.55)]ng·L^(-1)、FFA水平为(0.29±0.08)mmol·L^(-1),均低于同期对照组(P<0.05)。(5)治疗后,两组患者中医证候积分低于治疗前,治疗组积分为[2.00(1.00,2.00)]分,低于同期对照组(P<0.05)。(6)治疗组有效率为96.97%(32/33),对照组有效率为93.55%(29/31),两组有效率比较,差异有统计学意义(P<0.
Objective:To observe the effect of Xiaozhi Hugan Capsule developed by Professor Zhao Wenxia,a famous traditional Chinese medicine,on hepatic steatosis in patients with phlegm-dampness and blood stasis type nonalcoholic steatohepatitis,and to provide evidence for rational clinical medication.Methods:Using SPSS25.0 statistical software,72 patients who met the inclusion criteria were randomly divided into treatment group and control group according to the order of enrollment,with 36 cases in each group.On basis of exercise and dietary guidance,the treatment group was given Xiaozhi Hugan Capsule,a hospital preparation,three times a day and three capsules each time.The control group took polyene phosphatidylcholine capsules(Yishanfu)orally,3 times a day,2 capsules each time,and the course of treatment in both groups was 3 months.The controlled attenuation parameter CAP value,alanine aminotransferase(ALT),aspartate aminotransferase(AST),total cholesterol(TC)of liver transient elastography were compared between the two groups before and after treatment.TC,triglyceride(TG),high-density lipoprotein(HDL-C),interleukin-6(IL-6),free fat acid(FFA)and TCM syndrome score and compare the curative effects of TCM syndrome between the two groups.Results:(1)After treatment,the CAP values of both groups were lower than those before treatment;The CAP value of the treatment group was(248.24±22.80)dB·m^(-1),which was lower than that of the control group(P<0.05).(2)After treatment,the levels of ALT and AST in both groups decreased significantly;The levels of ALT and AST in the treatment group were(36.82±10.46)U·L^(-1)and(26.87±6.99)U·L^(-1),respectively,which were lower than those in the control group(P<0.05).(3)After treatment,the levels of TG and TC in both groups were lower than before treatment,and the level of HDL-C was significantly higher than before treatment.The levels of TG and TC in the treatment group were[1.21(0.95,1.37)]mmol·L^(-1)and(3.53±0.71)mmol·L^(-1),respectively,which were lower than those in the control gro
作者
万一心
赵文霞
刘晓彦
WAN Yixin;ZHAO Wenxia;LIU Xiaoyan(Henan University of Chinese Medicine,Zhengzhou Henan China 450046;The First Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450000)
出处
《中医学报》
CAS
2023年第9期1985-1991,共7页
Acta Chinese Medicine
基金
河南省中医药科学研究专项课题项目(2019JDZX2012)。
关键词
非酒精性脂肪性肝炎
痰湿瘀阻证
消脂护肝胶囊
肝脂肪变
炎症因子
nonalcoholic steatohepatitis
syndrome of Phlegm-Dampness and blood stasis
Xiaozhi Hugan Capsule
hepatic steatosis
inflammatory factor
