摘要
目的 快速评价帕洛诺司琼预防化疗所致恶心呕吐(chemotherapy induced nausea vomiting,CINV)的有效性、安全性及经济性,为临床药物选择提供循证依据。方法 计算机检索主要的中英文数据库,纳入帕洛诺司琼预防CINV的卫生技术评估报告、系统评价/meta分析及药物经济学研究,对纳入的文献进行质量评价和汇总分析。结果 共纳入17篇文献,包括7篇系统评价/meta分析和10篇药物经济学研究。有效性方面,与第一代5-羟色胺3受体拮抗剂相比,帕诺洛司琼在急性、延迟性及全程CINV控制率上均有明显优势。安全性方面,对照组和观察组常见不良反应发生率差异无统计学意义(P>0.05)。帕诺洛司琼的有效率高于其他5-羟色胺3受体拮抗剂,但成本较高,需要比较意愿支付阈值确定其经济性。结论 帕诺洛司琼对预防CINV具有较好的有效性和安全性,但经济性还需要深入研究。
Objective To rapidly evaluate the efficacy,safety and economy of palonosetron in the prevention of chemotherapy-induced nausea and vomiting(CINV),so as to provide evidence-based support for clinical drug use.Methods By retrieving several major Chinese and English database,systematic reviews/Meta-analysis,HTA and pharmacoeconomic studies about palonosetron in the prevention of CINV were included,and the quality evaluation and summary analysis of the included literature were performed.Results A total of 17 literatures were included,involving 7 systematic reviews/meta-analysis and 10 pharmacoeconomic studies.In terms of effectiveness,compared with the first generation 5-HT3RAs,palonosetron had obvious advantages in the complete control rate of CINV in acute phases,delay phases and overall phases.In terms of safety,there was no statistical significance in the incidence of common ADR between palonosetron and other 5-HT3RAs.Pharmacoeconomic studies showed that the efficacy of palonosetron was higher than other 5-HT3RAs,but the cost was higher as well.It is necessary to compare the threshold of willingness to pay(WTP)to determine its economy.Conclusion Palonosetron has good efficacy and safety in the prevention of chemotherapy-induced nausea and vomiting,but the economy needs to be further verified.
作者
尤越
徐小菊
范国荣
YOU Yue;XU Xiaoju;FAN Guorong(Department of Clinical Pharmacy,Shanghai General Hospital,Shanghai Jiao Tong University,Shanghai 200080,China)
出处
《世界临床药物》
CAS
2023年第6期580-586,共7页
World Clinical Drug
