摘要
目的通过病例对照研究探讨早发冠心病的多重危险因素,筛选出早发冠心病新的独立危险因素,为冠心病的防治提供新的思路和数据支持。探寻早发冠心病与中医体质的关系,在冠心病的防治过程当中充分发挥中医“治未病”的思想,通过调节体质和规避危险因素做到未病先防。方法采用病例对照研究调查2021年1月至2022年2月就诊于北京中医药大学东直门医院心血管内科的早发冠心病患者关于危险因素的一般情况、睡眠情况及中医体质,采用SPSS26.0进行统计分析。结果吸烟(OR=5.966,95%CI:2.240~15.891)、高脂血症(OR=9.016,95%CI:3.543~22.943)、早发冠心病家族史(OR=4.224,95%CI:1.505~11.856)、睡眠障碍(OR=3.567,95%CI:1.495~8.509)为早发冠心病的独立危险因素。病例组匹兹堡睡眠质量指数量表(PSQI)各维度得分及总分均高于对照组,入睡时间晚于23:00是危险因素(OR=2.405,95%CI:1.328~4.356),无午休习惯是保护性因素(OR=0.495,95%CI:0.275~0.891)。病例组中体质要素分布频次较高的为气虚质要素57次、痰湿质要素47次、血瘀质要素33次,气虚质为危险体质(OR=5.412,95%CI:2.295~12.762),平和质为保护性体质(OR=0.239,95%CI:0.092~0.619)。结论吸烟、血脂异常、冠心病家族史、睡眠障碍是早发冠心病的独立危险因素。睡眠情况方面发现入睡时间晚于23:00是早发冠心病的危险因素,不午休可能是早发冠心病的保护性因素。中医体质方面发现气虚质为早发冠心病的危险体质而平和质是保护性体质。
Objective:To explore the multiple risk factors of premature coronary heart disease(PCHD)and screen out new independent risk factors through a case-control study,which will provide new ideas and data support for the prevention and treatment.To explore the relationship between PCHD and traditional Chinese medi⁃cine(TCM)constitution,and give full play to the idea of“preventing diseases before treatment”,so as to prevent the disease before it happens by regulating the TCM constitution and avoiding risk factors.Methods:A casecontrol study was used to investigate the general condition,sleep condition and TCM constitution in PCHD patients who visited the Cardiovascular Medicine Department of Dongzhimen Hospital,Beijing University of Tradi⁃tional Medicine from January 2021 to February 2022,and SPSS 26.0 was used for statistical analysis.Results:Smoking(OR=5.966,95%CI:2.240~15.891),hyperlipidemia(OR=9.016,95%CI:3.543~22.943),family history of PCHD(OR=4.224,95%CI:1.505~11.856),and sleep disorder(OR=3.567,95%CI:1.495~8.509)were inde⁃pendent risk factors.The PSQI scores and total scores were higher in the case group than that in the control group.Sleep time later than 23:00 was a risk factor(OR=2.405,95%CI:1.328~4.356),and no lunch break habit was a protective factor(OR=0.495,95%CI:0.275~0.891).The higher frequency of distribution of constitution elements in the case group was 57 times for qi deficiency elements,47 times for phlegm-damp elements,and 33 times for blood stasis elements,with qi deficiency being the risky constitution(OR=5.412,95%CI:2.295~12.762)and the mild constitution being the protective constitution(OR=0.239,95%CI:0.092~0.619).Conclusion:Smok⁃ing,dyslipidemia,family history of PCHD,and sleep disorders are independent risk factors for PCHD.As for sleep conditions,sleeping later than 23:00 is a risk factor,and not taking a lunch break may be a protective factor.In terms of TCM constitution,the qi deficiency constitution is a risk constitution,while the mild constitution is a pro⁃tective constitu
作者
张晶芳
曾圆圆
赵静
翁洁琼
原梦飞
沈晓旭
Zhang Jingfang;Zeng Yuanyuan;Zhao Jing;Weng Jieqiong;Yuan Mengfei;Shen Xiaoxu(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《中国中医急症》
2023年第8期1368-1372,共5页
Journal of Emergency in Traditional Chinese Medicine
基金
国家科技部重点研发计划(2017YFC1700206)。
关键词
早发冠心病
危险因素
睡眠障碍
中医体质
Premature coronary heart disease
Risk factor
Sleep disorder
Traditional Chinese Medicine consti⁃tution
