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阿立哌唑胶囊联合碳酸锂片及丙戊酸钠片治疗双相情感障碍躁狂发作的效果研究

Therapeutic effect of aripiprazole capsules combined with lithium carbonate tablets and sodium valproate tablets on manic episodes of bipolar disorder
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摘要 目的探讨阿立哌唑胶囊联合碳酸锂片及丙戊酸钠片治疗双相情感障碍躁狂发作的效果。方法抽取2019年10月至2021年9月南阳市第一人民医院收治的双相情感障碍躁狂发作患者86例,按随机数字表法分为三药组与双药组,每组43例。双药组采用碳酸锂片、丙戊酸钠片治疗,三药组在双药组治疗基础上联合阿立哌唑胶囊治疗。比较两组临床疗效、贝克-拉范森躁狂量表(BRMS)量表评分、阳性与阴性症状量表(PANSS)评分、威斯康星片分类测验(WCST)评分、持续操作测验(CPT)评分、白细胞介素-10(IL-10)、白细胞介素-1(IL-1)水平及不良反应发生情况。结果三药组总有效率(95.35%,41/43)高于双药组(81.40%,35/43),差异有统计学意义(χ^(2)=4.07,P=0.044)。治疗后,三药组BRMS、PANSS评分低于双药组,WCST、CPT评分高于双药组(P<0.05)。治疗后,三药组IL-10水平高于双药组,IL-1水平低于双药组(P<0.05)。三药组不良反应发生率(11.63%,5/43)与双药组(9.30%,4/43)比较差异未见统计学意义(P=1.000)。结论阿立哌唑胶囊联合碳酸锂片、丙戊酸钠片治疗双相情感障碍躁狂发作可提高疗效,改善患者的认知功能、躁狂程度与精神状况,调节炎症状态,存在用药安全性。 Objective To investigate the effect of aripiprazole capsules combined with lithium carbonate tablets and sodium valproate tablets in the treatment of manic episodes of bipolar disorder.Methods A total of 86 patients with manic episodes of bipolar disorder treated in Nanyang First People’s Hospital from October 2019 to September 2021 were selected,and they were divided into three-drug group and two-drug group according to random number table method,with 43 cases in each group.The two-drug group was treated with lithium carbonate tablets combined with sodium valproate tablets,and the three-drug group was treated with aripiprazole capsules based on the treatment of the two-drug group.The clinical efficacy,Bech-Rafaelsen mania rating scale(BRMS)score,positive and negative syndrome scale(PANSS)score,Wisconsin card sorting test(WCST)score,continuous performance test(CPT)score,interleukin-10(IL-10)level,interleukin-1(IL-1)level and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the three-drug group(95.35%,41/43)was higher than that of the two-drug group(81.40%,35/43),and the difference was significant(χ^(2)=4.07,P=0.044).After treatment,the scores of BRMS and PANSS in the three-drug group were lower than those in the two-drug group,while scores of WCST and CPT in the three-drug group were higher than those in the two-drug group(P<0.05).After treatment,the level of IL-10 in the three-drug group was higher than that in the two-drug group,and the level of IL-1 was lower than that in the two-drug group(P<0.05).There was no significant difference in the incidence of adverse reactions between the three-drug group(11.63%,5/43)and the two-drug group(9.30%,4/43),P=1.000.Conclusions Aripiprazole capsules combined with lithium carbonate tablets and sodium valproate tablets in the treatment of manic episodes of bipolar disorder can improve the efficacy,improve cognitive function,manic degree and mental status,and regulate inflammatory state,with drug safety.
作者 陈铎 刘锐 梁春生 Chen Duo;Liu Rui;Liang Chunsheng(Department of Psychiatry,Nanyang First People’s Hospital,Nanyang 473000,China;Department of Psychiatry,Nanyang Fourth People’s Hospital,Nanyang 473000,China)
出处 《中国实用医刊》 2023年第10期112-115,共4页 Chinese Journal of Practical Medicine
关键词 双相情感障碍 躁狂发作 阿立哌唑胶囊 碳酸锂片 丙戊酸钠片 Bipolar disorder Manic episode Aripiprazole capsules Lithium carbonate tablets Sodium valproate tablets
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