摘要
目的 分析二甲双胍联合吡格列酮治疗2型糖尿病的临床效果。方法 2020年1月-2022年10月期间于选取无锡市惠山区第二人民医院治疗的67例2型糖尿病患者为研究对象,通过随机数表法分为两组,对照组(n=33)接受盐酸二甲双胍片治疗,观察组(n=34)接受盐酸二甲双胍片联合盐酸吡格列酮片治疗,对比两组患者临床治疗效果。结果 观察组总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗前的空腹血糖(fasting plasma glucose, FPG)、餐后2 h血糖(2 hour postprandial blood glucose, 2 hPG)、糖化血红蛋白(glycated hemoglobin, HbA1c)、三酰甘油(triacylglycerol, TG)、总胆固醇(total cholesterol, TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol, LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol, HDL-C)水平对比,差异无统计学意义(P>0.05);两组治疗后的FPG、2 hPG、HbA1c、TC、TG、HDL-C、LDL-C水平均优于治疗前,且观察组优于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论 2型糖尿病患者在临床治疗时采取二甲双胍与吡格列酮联合用药方案,不仅对患者机体血糖、血脂水平具有非常好的改善作用,并且患者在用药期间无明显的不良反应,可以确保患者用药安全,这两种药物联合使用对2型糖尿病患者群体病情改善具有重要的意义。
Objective To analyze the clinical effect of metformin combined with pioglitazone in the treatment of type 2 diabetes mellitus.Methods 67 patients with type 2 diabetes who were treated in the Second People's Hospital of Huishan District,Wuxi City from January 2020 to October 2022 were selected as the research objects.They were divided into two groups by random number table method.The control group(n=33)received metformin hydrochloride tablets,and the observation group(n=34)received Metformin hydrochloride tablets combined with pioglitazone hydrochloride tablets.The clinical treatment effects of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the levels of fasting plasma glucose(FPG),2-hour postprandial blood glucose(2 hPG),glycated hemoglobin,(HbA1c),triacylglycerol(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),LDL-C,high density lipoprotein cholesterol(HDL-C)between the two groups before treatment(P>0.05).The levels of FPG,2 hPG,HbA1c,TC,TG,HDL-C,and LDL-C in the two groups after treatment were better than before treatment,and the observation group were better than the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05).Conclusion The combination of metformin and pioglitazone in the clinical treatment of type 2 diabetes mellitus patients not only has a very good improvement on the patients'blood glucose and lipid lev‐els,but also has no obvious adverse reactions during the medication,which ensures the safety of the patients'medica‐tion,and the combined use of these two drugs is of great significance for the improvement of the condition of type 2 diabetes mellitus patient groups.
作者
施红杰
陈婷
潘琼
SHI Hongjie;CHEN Ting;PAN Qiong(Department of Endocrinology,the Second People's Hospital of Huishan District,Wuxi,Jiangsu Province,214100 China)
出处
《糖尿病新世界》
2023年第13期109-112,共4页
Diabetes New World Magazine
关键词
二甲双胍
吡格列酮
2型糖尿病
Metformin
Pioglitazone
Type 2 diabetes mellitus
