摘要
急性肺栓塞(APE)在我国具有较高的病死率,尽早对APE患者进行正确的危险分层能够改善患者预后。传统的危险分层是根据患者的血流动力学作为参考,目前APE患者的肺动脉压力是临床关注的热点,APE合并肺动脉高压患者的临床不良事件发生率普遍升高。同时一些生物标志物如脑钠肽、D-二聚体、肌钙蛋白I与肺动脉压力存在相关性,该类指标对APE患者危险分层和预后也具有参考价值。本文就APE病理生理和肺动脉压力及联合上述三种生物标志物在APE患者中危险分层及预后进行综述,为APE危险分层提供新思路。
Acute pulmonary embolism(APE)has a high mortality rate in China.Early correct risk stratification of APE patients can improve the prognosis of patients.The traditional risk stratification is based on the patient’s hemodynamics as a reference.Currently,pulmonary arterial pressure in APE patients is a hot topic of clinical attention,and the incidence of clinical adverse events in APE patients with pulmonary arterial hypertension is generally increased.At the same time,some biomarkers,such as brain natriuretic peptide,D-dimer,cardiac troponin I are related to pulmonary artery pressure.These indicators also have reference value for risk stratification and prognosis of APE patients.This article reviews the pathophysiology and pulmonary artery pressure of APE,as well as the combination of the three biomarkers mentioned above,in the risk stratification and prognosis of APE patients,providing new ideas for APE risk stratification.
作者
仵楠
邢西迁
杨姣
WU Nan;XING Xiqian;YANG Jiao(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Kunming Medical University,Yunnan Province,Kunming 650032,China;Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Yunnan University,Yunnan Province,Kunming 650021,China)
出处
《中国医药导报》
CAS
2023年第22期56-59,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81760015)
云南省高层次人才培养支持计划“名医”专项
云南省卫生健康委员会医学后备人才培养计划项目(H-2018095)。
关键词
急性肺栓塞
肺动脉高压
危险分层
研究进展
Acute pulmonary embolism
Pulmonary hypertension
Risk stratification
Research progress
