摘要
内皮脂肪酶(EL)主要由血管内皮细胞生成,负责调控肝脏脂质代谢及肠道脂质吸收。在炎性状态下EL可促进巨噬细胞及血小板在受损血管内皮黏附、聚集;EL还可促进受损血管内皮细胞增殖,抑制EL的过表达可减轻动脉粥样硬化病变程度。但在急性冠脉病变及氧化应激反应时EL却能增强高密度脂蛋白胆固醇抗氧化能力减轻炎性反应对血管内皮损伤,增强受损心肌细胞能量代谢能力抑制受损心肌细胞凋亡。EL抑制剂作为血脂代谢紊乱、动脉粥样硬化疾病新型治疗用药还需更广泛药物临床试验明确其真实临床疗效、安全性及具体临床适用场景。
Endothelial lipase(EL)is mainly generated by vascular endothelial cells and is responsible for regulating liver lipid metabolism and intestinal lipid absorption.In the inflammatory state,EL can also promote the adhesion and aggregation of macrophages and platelets in the damaged vascular endothelium.EL can also promote the proliferation of damaged vascular endothelial cells,and inhibit the over-expression of EL can reduce the degree of atherosclerosis.However,in acute coronary artery disease and oxidative stress reaction,EL can enhance the antioxidant capacity of high-density lipoprotein cholesterol,reduce the damage of inflammatory reaction to vascular endothelium,enhance the energy metabolism of damaged cardiomyocytes and inhibit apoptosis of damaged cardiomyocytes.As a new therapeutic drug for dyslipidemia and atherosclerosis,endothelial lipase inhibitor needs more extensive clinical trials to clarify its true clinical efficacy,safety and specific clinical application scenarios.
作者
宋星明
哈力沙·艾日肯江
迪丽胡玛尔·阿布来提
高颖
SONG Xingming;Harisa·ERKENJIAN;Dilihumal·ABLAITI;GAO Ying(The Third Department of General Internal Medicine,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《基础医学与临床》
2023年第9期1443-1447,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(81660040)。
关键词
内皮脂肪酶
脂代谢
炎性反应
动脉粥样硬化
冠心病(CHD)
endothelial lipase
lipid metabolism
inflammatory reaction
atherosclerosis
coronary heart disease(CHD)
