摘要
青藤碱是从中药青风藤中提取出来的一种异喹啉类生物碱,具有抗炎、镇痛、镇静、免疫抑制等活性,临床上广泛用于自身免疫疾病的临床治疗。近年来,其抗肿瘤作用受到广泛关注,研究发现青藤碱对乳腺癌具有治疗潜力,其在细胞增殖、凋亡、转移和血管生成等多种生物学过程中发挥着重要作用。笔者通过查阅国内外相关文献报道,对青藤碱抗乳腺癌作用及机制的研究进展进行综述,以期为青藤碱的进一步研究和临床应用提供科学依据和理论指导。
Sinomenine is an isoquinoline alkaloid extracted from Chinese medicine Sinomenii Caulis,with antiinflammatory,analgesia,sedation,immunosuppression and other activities,and is widely used in the clinical treatment of rheumatoid arthritis and other autoimmune diseases.Recently,its antitumor effect has received wide attention.It is found that sinomenine has therapeutic potential for breast cancer,which plays an important role in many biological processes such as cell proliferation,apoptosis,metastasis and angiogenesis.By consulting the latest relevant literature reports at home and abroad,the research progress of anti-breast cancer effect and mechanism of sinomenine are reviewed,which provides scientific basis and theoretical guidance for further research and clinical application of sinomenine.
作者
刘维
卡玉秀
王爱华
苟小平
陈婌娟
林芳芳
LIU Wei;KA Yuxiu;WANG Aihua;GOU Xiaoping;CHEN Shujuann;LIN Fangfang(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2023年第8期3735-3739,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家重点研发计划(No.2018YFC1705201)
国家自然科学基金面上项目(No.82074377)。
关键词
青藤碱
乳腺癌
作用机制
研究进展
Sinomenine
Breast cancer
Mechanism of action
Research progress
