摘要
目的分析乳头状肾细胞癌患者的临床病理特征及预后。方法选取2016年1月至2021年3月于本院接受治疗的30例乳头状肾细胞癌患者作为研究对象,并采取免疫组化染色鉴定检查,观察其免疫表型,对患者进行随访,分析乳头状肾细胞癌患者的临床特征、影像学表现特征、病理特征。结果临床特征:肿瘤部位主要包括左肾、右肾、肾上极、中下极,肾下极、中部及整个肾脏,发现方式主要通过体检、腰痛入院、肉眼血尿;影像学表现:超声可见肝肾内部回声不均匀,肿瘤出血、坏死、囊性病变,CT检查下可见肿瘤密度不均匀,不均匀强化,肾造影检查可见肿瘤血管网稀少;病理特征:手术后标本肿瘤直径大小不一,组织多为实性、切面黄、多彩状、灰红色及烂鱼状,肿瘤边界清楚,部分患者累及肾盂,可见肾外生长;利用电镜检查可见患者肿瘤病理特征表现为淋巴管内癌栓、肾小球样结构、含铁血黄素沉积、泡沫细胞、内瘤样结构、纤维性假包膜、局灶性透明细胞癌;病理组织分型多为一型、二型;患者免疫组化染色结果:患者的EMA、CK7、CKpan、CD10、p504s、CK20、34βE12均出现阳性例数;对所有患者均采取随访措施后可见,8例二型患者均死于术后3、7、9月,2例一型患者死于术后3、5个月,其余患者均无瘤生存。结论乳头状肾细胞癌的临床病理特征、临床特征、影像学等表现特征复杂多样,存在一定肿瘤侵袭性,预后不佳,临床应提高对乳头状肾细胞癌患者的诊疗水平,提高患者生存率。
Objective To analyze the clinicopathological characteristics and prognosis of patients with papillary renal cell carcinoma.Methods 30 patients with papillary renal cell carcinoma treated in our hospital from January 2016 to March 2021 were selected as the study subject,examined immunohistochemical staining to observe the immunophenotype,and followed all patients to analyze the clinical characteristics,imaging characteristics and pathological characteristics of patients with papillary renal cell carcinoma.Results The clinical characteristics:the tumor site mainly included the left kidney,right kidney,upper kidney pole,middle and lower kidney pole,lower lower pole,as well as the whole kidney,the main detection method was through physical examination,low back pain admission,gross hematuria;the imaging findings:the ultrasound showed an uneven echo within the liver and kidney,tumor hemorrhage,necrosis,cystic lesions,uneven tumor density was seen under the CT examination,ununiform reinforcement,nephrography showed sparse tumor vascular network;the pathological features:tumor diameter sizes after surgery,the organization was mostly solid,cut yellow,colorful,gray red and rotten fish shape,tumor lines were well-circumscribed,some patients involving the renal pelvis,outer renal growth was visible;by electron microscopic examination,the pathological characteristics of the tumor were lymphatic carcinoma thrombus,glomerular-like structure,hemosiderin deposition,foam cells,internal tumor-like structure,fibrous pseudocapsule,and focal clear cell carcinoma;pathological tissue classification is mostly of typeⅠand typeⅡ;the results of the immunohistochemical staining of the patients were visible,patients were positive for EMA,CK7,CKpan,CD10,p504s,CK20,and 34βE12;be seen after taking follow-up measures in all patients,all eight patients died after postoperative 3,7 and September,two typeⅠpatients died at 3 and 5 months after surgery,all of the remaining patients had tumor-free survival.Conclusion The clinicopathological char
作者
邹丽
胡艳
安金
ZOU Li;HU Yan;AN Jin(Department of Pathology,First People's Hospital of Fuzhou,Fuzhou,Jiangxi,344000,China)
出处
《当代医学》
2023年第9期164-167,共4页
Contemporary Medicine
关键词
乳头状肾细胞癌
临床病理
免疫组化
Papillary renal cell carcinoma
Clinicopathological features
Immunohistochemistry
