摘要
目的 研究脂蛋白相关磷脂酶A2(Lp-PLA2)对急性脑梗死患者合并颅内外动脉粥样硬化性狭窄的预测价值。方法 回顾性收集2019年5月至2022年4月就诊于山东省千佛山医院神经内科的1 045例急性脑梗死患者的临床资料,根据患者的性别及血管狭窄部位分为男性无血管狭窄组(n=282)、男性颅内动脉狭窄组(n=265)、男性颅外动脉狭窄组(n=105)、女性无血管狭窄组(n=173)、女性颅内动脉狭窄组(n=156)、女性颅外动脉狭窄组(n=64)。采用多因素Logistic回归分析Lp-PLA2与颅内外血管狭窄的相关性。结果 不同年龄、性别、卒中史、冠心病史、同型半胱氨酸水平患者的Lp-PLA2水平比较,差异均有统计学意义(均P<0.05)。3组男性患者的不同Lp-PLA2水平的患者占比比较,差异有统计学意义(χ^(2)=65.276,P<0.01)。3组女性患者的Lp-PLA2水平患者占比比较,差异无统计学意义(χ^(2)=7.061,P>0.05)。多因素Logistic回归分析结果显示,Lp-PLA2水平为520.3~606.5 IU/L(OR=1.842,95%CI=1.060~3.199,P=0.030)、>606.5 IU/L(OR=3.966,95%CI=2.174~7.235,P<0.001)是男性急性脑梗死患者合并颅内动脉狭窄的危险因素;在女性患者中,未发现Lp-PLA2水平与颅内外动脉狭窄风险相关(P>0.05)。结论 男性急性脑梗死合并颅内动脉狭窄患者的Lp-PLA2水平升高,Lp-PLA2可能作为男性急性脑梗死患者颅内动脉狭窄的一项预测指标。
Objective To investigate the predictive value of lipoprotein-associated phospholipase A2 (Lp-PLA2) in acute cerebral infarction patients with atherosclerotic stenosis of intracranial and extracranial arteries. Methods Retrospectively, a total of 1 045 patients with acute cerebral infarction who visited the Department of Neurology in Shandong Provincial Qianfoshan Hospital from May 2019 to April 2022 were selected. According to gender and location of stenosis of patients with cerebral infarction, they were divided into male non-cerebral atherosclerotic stenosis group (n=282), male intracranial atherosclerotic stenosis group (n=265), male extracranial atherosclerotic stenosis group (n=105), female non-cerebral atherosclerotic stenosis group (n=173), female intracranial atherosclerotic stenosis group (n=156), female extracranial atherosclerotic stenosis group (n=64). The correlation between Lp-PLA2 and symptomatic intracranial and extracranial stenosis was analyzed by multifactor Logistic regression. Results The comparison of Lp-PLA2 levels in patients with different age, gender, stroke history, coronary heart disease history, and homocysteine levels was statistically significant (P< 0.05). The comparison of the number of patient cases with different Lp-PLA2 levels among male patients in the 3 groups showed a statistically significant difference (χ^(2) =65.276, P < 0.01). However, there was no significant differences in the comparison of the number of patient cases with different Lp-PLA2 levels among the three groups in female patients(χ^(2) =7.061,P> 0.05). Multifactor Logistic regression analysis showed that Lp-PLA2 levels of 520.3 to 606.5 IU/L (OR=1.842, 95%CI=1.060 to 3.199, P=0.030) and > 606.5 IU/L (OR=3.966, 95%CI=2.174 to 7.235, P < 0.001) were risky factors for the combination of intracranial atherosclerotic stenosis in male patients with acute cerebral infarction, whereas no association was found between Lp-PLA2 and the risk of intracranial or extracranial atherosclerotic stenosis in female patients (P
作者
林洁
王爱华
Lin Jie;Wang Aihua(Qilu Medical College,Shandong University,Jinan 250012,China;Department of Neurology,the First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,Shandong Institute of Neuroimmunology,Shandong Key Laboratory of Rheumatic Disease and Translational Medicine,Jinan250013,China)
出处
《神经疾病与精神卫生》
2023年第8期544-549,共6页
Journal of Neuroscience and Mental Health
基金
山东省重点研发计划(2019GSF108033)。
关键词
动脉粥样硬化
急性脑梗死
脂蛋白相关磷脂酶A2
危险因素
Atherosclerosis
Acute cerebral infarction
Lipoprotein-associated phospholipase A2
Risk factor
