摘要
帕金森病(PD)是好发于中老年人群的常见神经退行性疾病,其病因与老化、遗传、环境因素密切相关,运动症状与非运动症状随疾病进展不断加重,导致患者生活质量下降。药物治疗及神经调控治疗是目前PD的主要治疗手段,但只能改善患者的临床症状,无法治愈疾病,且尚无明确的可延缓疾病进程的手段。PD前驱期预警、早期诊断及开展疾病修饰治疗研究的意义重大,多学科诊疗模式及患者参与其中的全疾病周期管理能够更好地帮助患者改善生活质量。本文介绍了PD诊断及治疗的相关进展,以期加深对疾病的认识,探索新的治疗手段及疾病管理模式。
Parkinson disease(PD) is a common neurodegenerative disease in middle-aged and older adults.Its etiology is strongly related to degeneration,heredity,environment factors.Motor symptoms and nonmotor symptoms gradually worsen with disease progression which can reduce quality of life of patients.Drug therapy and neuromodulatory therapy are currently the main treatment methods for PD,but they can only improve the clinical symptoms of patients and can not cure the disease.There is no definite means to delay the progression of the disease.The PD prodromal warning,early diagnosis,and research on disease modification therapy is of great significance.Multidisciplinary diagnosis and treatment models and full disease cycle management involving patients can better help patients improve their quality of life.This article introduces the relevant progress in the diagnosis and treatment of PD,in order to deepen understanding of the disease,explore new treatment methods and disease management models.
作者
毛薇
Mao Wei(Department of Neurology,Xuanwu Hospital,Capital Medical University,National Clinical Research Center for Geriatric Disorders,Beijing 100053,China)
出处
《神经疾病与精神卫生》
2023年第8期533-537,共5页
Journal of Neuroscience and Mental Health
关键词
帕金森病
诊断
治疗
管理
综述
Parkinson disease
Diagnosis
Treatment
Management
Review
