摘要
目的 了解当前热量限制和热量限制模拟物在炎症性疾病中的研究现状。方法 检索国内外相关研究的文献,对热量限制及热量限制模拟物影响免疫细胞、炎症反应及它在临床应用的相关研究进行综述并分析。结果 热量限制作为一种饮食疗法,通过限制每日的能量摄入,调节细胞代谢途径及能量模式而影响免疫系统和功能,减轻炎症反应程度及改善机体症状,它在衰老、2型糖尿病、心血管疾病、骨关节炎、神经退行性疾病中得到越来越多的重视。同时,研究发现一些热量限制模拟物如白藜芦醇、雷帕霉素、二甲双胍等在产生同热量限制相似效果的同时而不需要严格限制饮食。结论 目前对热量限制的研究较多,但目前仍无公认且统一的热量限制方案,使之难以在临床实践中应用;热量限制模拟物的出现,在产生同热量限制相似效果的同时而不需要严格限制饮食,更符合人体生理并使患者受益。目前对这些药物如何通过调节代谢途径来预防炎症有了一定的认识,其间关系复杂,未来可优先考虑将免疫代谢这一新领域提出的知识应用于预防与年龄相关疾病中的炎症,并将抗炎药物重新用作治疗与年龄相关疾病的治疗选择。
Objective To understand the current research status of calorie restriction and calorie restriction mimetics in inflammatory diseases.Method The literatures about the effect of caloric restriction and caloric restriction mimetics on immune cells,inflammatory responses,and clinical applications were reviewed and analyzed.Results As a dietary therapy,the caloric restriction affected the immune system and function by limiting daily energy intake,regulating cellular metabolic pathways and energy patterns,reducing the inflammatory reaction and improving body symptoms.A growing numbers of attention had been paid in aging,type 2 diabetes,cardiovascular disease,osteoarthritis,neurodegenerative diseases,etc.And it was found that some caloric restriction mimetics such as resveratrol,rapamycin,metformin,etc.could not only achieve similar effects with caloric restriction,but also did not need to strictly restrict diet.Conclisions Although calorie restriction has been studied extensively,there is still no widely accepted and uniform calorie restriction protocol,which is challenging in clinical practice.The development of calorie restriction mimetics,which has similar effects to calorie restriction without requiring strict dietary restriction,is more in line with human physiology and is advantageous to patients.There is a certain understanding how these drugs can prevent inflammation by regulating metabolic pathways,and the relation between them is complex.In future,the knowledge proposed in new field of immunometabolism is preferred to prevent inflammation in age-related diseases,and antiinflammatory drugs should be reused as a therapeutic option for treatment of age-related diseases.
作者
王铎
张熙冰
韩磊
苏秋铭
冉江华
WANG Duo;ZHANG Xibing;HAN Lei;SU Qiuming;RAN Jianghua(Department of Hepatobiliary and Pancreatic Surgery,Calmete Hospital Affiliated to Kunming Medical University,Kunming 650100,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2023年第8期982-987,共6页
Chinese Journal of Bases and Clinics In General Surgery
基金
国家自然科学基金项目(项目编号:82060127)
昆明医科大学研究生创新基金(项目编号:2022S103)。
关键词
热量限制
热量限制模拟物
炎症
caloric restriction
caloric restriction mimetics
inflammation
