摘要
目的探究阿托伐他汀联合微创穿刺治疗慢性硬膜下血肿疾病的临床疗效。方法选取2018年3月至2021年10月本院神经外科收治的45例慢性硬膜下血肿疾病患者作为研究对象,采用中心数字分层法分为甲组(n=20)与乙组(n=25)。甲组给予微创穿刺治疗,乙组在甲组基础上联合阿托伐他汀治疗,比较两组血肿量、认知功能[简易精神状态评估量表(MMSE)]、Markwader分级情况、复发情况、时间指标、再手术情况、预后情况、术后并发症发生率、生命质量及独立生活能力。结果两组血肿量及MMSE评分组间、时间、交互比较差异有统计学意义(P<0.05)。组内比较:术后3、6个月,两组术后各时间点血肿量均少于前一时间点,MMSE评分均高于前一时间点,差异有统计学意义(P<0.05)。组间比较:术后1、3、6个月,乙组血肿量均少于甲组,MMSE评分均高于甲组,差异有统计学意义(P<0.05)。乙组总改善率为100.00%,高于甲组的50.00%,差异有统计学意义(P<0.05)。乙组复发率为0.00%,低于甲组的25.00%,差异有统计学意义(P<0.05)。乙组症状消失时间、住院时间均短于甲组,差异有统计学意义(P<0.05)。乙组再手术率为0.00%,低于甲组的25.00%,差异有统计学意义(P<0.05)。乙组残疾占比低于甲组,无神经功能障碍占比高于甲组,差异有统计学意义(P<0.05);两组死亡占比比较差异无统计学意义。乙组并发症发生率低于甲组,差异有统计学意义(P<0.05)。两组生命质量评分组间、时间比较差异有统计学意义(P<0.05);两组生命质量评分交互比较差异无统计学意义。组内比较:术后3、6个月,两组术后各时间点生命质量评分均高于前一时间点,差异有统计学意义(P<0.05)。组间比较:术后1、3、6个月,乙组生命质量评分均高于甲组,差异有统计学意义(P<0.05)。两组独立生活能力评分组间、时间、交互比较差异有统计学意义(P<0.05)。组内比较:术后3、6�
Objective To explore the clinical efficacy of atorvastatin combined with minimally invasive puncture in the treatment of chronic subdural hematoma disease.Methods 45 patients with chronic subdural hematoma disease admitted to the department of Gastrointestinal Neurosurgery of our hospital from March 2018 to October 2021 were selected as the research subjects,they were divided into the group A(n=20)and the group B(n=25)according to central digital stratification.The group A was treated with minimally invasive puncture,and the group B was treated with atorvastatin on the basis of the group A,the hematoma volume,cognitive function(mini-mental state examination[MMSE]),Markwader classification,recurrence,time index,reoperation,prognosis,postoperative complication rate,quality of life and independent living ability were compared between the two groups.Results There were significant differences in hematoma volume and MMSE between the two groups of group,time points and interaction(P<0.05).Comparison within the group:3 and 6 months after operation,the hematoma volume at each time point after operation of the two groups was less than that at the previous time point,and the MMSE score was higher than that at the previous time point,and the differences were statistically significant(P<0.05).Comparison between groups:at 1,3 and 6 months after operation,the hematoma volume in the group B was less than that in the group A,and the MMSE score was higher than that in the group A,the differences were statistically significant(P<0.05).The total improvement rate in the group B was 100.00%,which was higher than 50.00%in the group A,the difference was statistically significant(P<0.05).The recurrence rate in the group B was 0.00%,which was lower than 25.00%in the group A,and the difference was statistically significant(P<0.05).The disappearance time of symptoms and hospitalization time in the group B were shorter than those in the group A,the differences were statistically significant(P<0.05).The reoperation rate in the group B was 0.0
作者
张斌
陈飞
张露
ZHANG Bin;CHEN Fei;ZHANG Lu(Department of Gastrointestinal Neurosurgery,Chongqing Thirteenth People's Hospital,Chongqing,400053,China)
出处
《当代医学》
2023年第18期1-5,共5页
Contemporary Medicine
