摘要
目的分析缺血修饰白蛋白(IMA)在急性心肌缺血早期诊断中的临床应用。方法选取2020年11月至2021年10月本院收治的60例急性冠状动脉综合征患者作为观察组,另选取同期60例慢性稳定型心绞痛患者作为对照1组,60例非缺血性心脏病患者作为对照2组。比较3组IMA的白蛋白钴结合(ACB)实验值及血清心肌肌钙蛋白T(cTnT)、肌红蛋白(Myo)、肌酸激酶同工酶(CK-MB)水平;比较急性冠状动脉综合征患者中不稳定型心绞痛与急性心肌梗死患者ACB值;分析IMA单独及IMA与cTnT、Myo、CK-MB联合应用诊断急性冠状动脉综合征的价值。结果观察组IMA的ACB值均低于对照1组与对照2组,差异有统计学意义(P<0.05);3组cTnT、Myo、CK-MB水平比较差异无统计学意义。急性冠状动脉综合征患者中不稳定型心绞痛患者ACB值为(63.51±15.66)KU/L,急性心肌梗死患者ACB值为(61.67±15.83)KU/L,两者比较差异无统计学意义。IMA单独诊断急性冠状动脉综合征的灵敏度均高于cTnT、Myo、CK-MB,差异有统计学意义(P<0.05);cTnT、Myo、CK-MB及联合诊断对急性冠状动脉综合征诊断的特异度高于IMA单独诊断,差异有统计学意义(P<0.05),联合诊断急性冠状动脉综合征的准确率高于IMA、cTnT、Myo及CK-MB单独诊断,差异有统计学意义(P<0.05)。结论IMA可在急性心肌缺血的发病早期敏感的反映心肌缺血状况,对疾病的早期诊断具有重要价值,但IMA单独用于该疾病的诊断的特异度较低,需与常规的cTnT、Myo、CK-MB心肌损伤标记物联合检测,以提高整体诊断准确率。
Objective To analyze the clinical application of ischemia modified albumin(IMA)in the early diagnosis of acute myocardial ischemia.Methods 60 patients with acute coronary syndrome admitted to our hospital from November 2020 to October 2021 were selected as the observation group,60 patients with chronic stable angina pectoris were selected as the control group 1,and 60 patients with non-ischemic heart disease were selected as the control group 2.The albumin cobalt binding(ACB)experimental value of IMA and the levels of serum cardiac troponin T(cTnT),myoglobin(Myo)and creatine kinase isoenzymes(CK-MB)were compared among the three groups;the ACB values of unstable angina pectoris and acute myocardial infarction in patients with acute coronary syndrome were compared,the value of IMA alone and IMA combined with cTnT,Myo and CK-MB in the diagnosis of acute coronary syndrome were analyzed.Results The ACB value of IMA in the observation group was lower than that in the control group 1 and the control group 2,and the differences were statistically significant(P<0.05);there were no significant differences in the levels of cTnT,Myo and CK-MB among the three groups.The ACB value of patients with unstable angina pectoris in patients with acute coronary syndrome was(63.51±15.66)KU/L,and the ACB value of patients with acute myocardial infarction was(61.67±15.83)KU/L,the difference was not statistically significant.The sensitivity of IMA in the diagnosis of acute coronary syndrome was higher than that of cTnT,Myo and CK-MB,and the differences were statistically significant(P<0.05);the specificity of cTnT,Myo,CK-MB and combined diagnosis in the diagnosis of acute coronary syndrome was higher than that of IMA alone,and the differences were statistically significant(P<0.05);the accuracy of combined diagnosis of acute coronary syndrome was higher than that of IMA,cTnT,Myo and CK-MB alone,and the differences were statistically significant(P<0.05).Conclusion IMA can sensitively reflect the condition of myocardial ischemia in the ear
作者
李杨
LI Yang(Tongren People's Hospital,Tongren,Guizhou,554300,China)
出处
《当代医学》
2023年第16期63-66,共4页
Contemporary Medicine
关键词
缺血修饰白蛋白
急性心肌缺血
早期
诊断
Ischemia modified albumin
Acute myocardial ischemia
Early
Diagnosis
