摘要
目的探讨营养支持对急性髓系白血病患者化疗效果及安全性的影响。方法选取丽水市中心医院2021年1-12月收治的急性髓系白血病患者130例,根据营养支持干预方法不同分为对照组、观察组各65例。对照组采用常规干预,观察组在常规干预基础上采用营养支持干预,两组干预至化疗后1个月。比较两组患者的化疗效果及安全性。结果观察组总有效率为92.3%(60/65),高于对照组的78.5%(51/65),差异有统计学意义(Z=4.91,P<0.05)。化疗后,观察组腰臀比、上臂围、体质量指数分别为0.9±0.1、(25.7±1.2)cm、(21.9±2.1)kg/m^(2),均显著高于对照组的0.8±0.1、(24.4±1.1)cm、(20.6±2.1)kg/m^(2)(t=4.13、6.63、3.64,均P<0.05);观察组转铁蛋白[(1.4±0.3)g/L]、清蛋白[(27.5±3.1)g/L]、前清蛋白[(171.3±11.3)mg/L]、血清总蛋白[(61.2±4.3)g/L]均显著高于对照组[(1.3±0.3)g/L、(25.2±2.9)g/L、(154.3±10.3)mg/L、(56.6±4.0)g/L](t=2.24、4.48、8.93、6.31,均P<0.05);观察组情绪状态[(57.5±4.6)分]、社会状态[(64.5±3.8)分]、角色认知[(56.5±4.1)分]、躯体感受[(62.0±4.2)分]均显著高于对照组[(47.9±4.2)分、(56.4±3.2)分、(47.7±4.5)分、(55.5±5.4)分](t=12.34、13.04、11.55、7.65,均P<0.05)。观察组不良反应发生率为9.2%(6/65),低于对照组的24.6%(16/65),差异有统计学意义(χ^(2)=4.43,P<0.05)。结论营养支持可显著提高急性髓系白血病患者的化疗效果,降低不良反应发生率,安全性好,值得临床推广。
Objective To investigate the effects of nutritional support on chemotherapeutic efficacy and safety in patients with acute myeloid leukemia.Methods A total of 130 patients with acute myeloid leukemia who received treatment in Lishui Municipal Central Hospital from January 2021 to December 2021 were included in this study.They were divided into a control group and an observation group(n=65/group)according to different nutritional support methods.Patients in the control group were given routine intervention,while patients in the observation group were given nutritional support based on routine intervention.These two interventions were administered till 1 month after chemotherapy.Chemotherapeutic efficacy and safety were compared between the two groups.Results Total response rate in the observation group was significantly higher than that in the control group[92.3%(60/65)vs.78.5%(51/65),Z=4.91,P<0.05].After chemotherapy,waist-to-hip ratio,arm girth,and body mass index in the observation group were(0.9±0.1),(25.7±1.2)cm,(21.9±2.1)kg/m^(2),respectively,which were significantly greater than(0.8±0.1),(24.4±1.1)cm,(20.6±2.1)kg/m^(2) in the control group,respectively(t=4.13,6.63,3.64,all P<0.05).Transferrin,albumin,prealbumin,and total serum protein in the observation group were(1.4±0.3)g/L,(27.5±3.1)g/L,(171.3±11.3)mg/L,and(61.2±4.3)g/L,respectively,which were significantly higher than(1.3±0.3)g/L,(25.2±2.9)g/L,(154.3±10.3)mg/L,(56.6±4.0)g/L respectively in the control group(t=2.24,4.48,8.93,6.31,all P<0.05).The scores of emotional state,social status,role cognition,and somatic perception in the observation group were(57.5±4.6)points,(64.5±3.8)points,(56.5±4.1)points,(62.0±4.2)points,which were significantly higher than(47.9±4.2)points,(56.4±3.2)points,(47.7±4.5)points,(55.5±5.4)points in the control group(t=12.34,13.04,11.55,7.65,all P<0.05).The total incidence of adverse reactions in the observation group was 9.2%(6/65),which was significantly lower than 24.6%(16/65)in the control group(χ^(2)=4.4
作者
杨丽超
方文娟
张隽瑜
Yang Lichao;Fang Wenjuan;Zhang Junyu(Department of Hematology,Lishui Municipal Central Hospital,Lishui 323000,Zhejiang Province,China)
出处
《中国基层医药》
CAS
2023年第8期1175-1179,共5页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省医药卫生科技计划(2020KY1078)。
关键词
营养支持
白血病
髓样
急性
药物疗法
联合
腰臀比
人体质量指数
转铁蛋白
总蛋白
治疗结果
药物相关性副作用和不良反应
Nutritional support
Leukemia,myeloid,acute
Drug therapy,combination
Waist-hip ratio
Body mass index
Transferrin
Total protein
Treatment outcome
Drug-related side effects and adverse reactions
