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原发性肝癌患者血清miR-6861-5p表达与其临床病理特征、生存时间的相关性研究

Expression of Serum mir-6861-5p in Patients with Primary Liver Cancer and Its Correlation with Clinicopathological Features and Survival Time
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摘要 目的探讨原发性肝癌患者血清微小RNA-6861-5p(miR-6861-5p)水平及临床意义。方法选择60例原发性肝癌患者作为研究对象,另外选择同期行常规体检的60例健康者作为对照组。所有入选者均检测血清miR-6861-5p水平。比较两组miR-6861-5p水平;并对所有肝癌患者均进行定期随访,分析miR-6861-5p与患者临床病理特征及其与患者生存时间的关系。结果肝癌组血清miR-6861-5p水平为(1.90±0.24),高于对照组(1.02±0.08),差异有统计学意义(P<0.05);不同病灶数量、肝硬化、肿瘤直径、病毒性肝炎患者血清miR-6861-5p水平相比,差异无统计学意义(P>0.05);淋巴结转移、肿瘤分期Ⅲ~Ⅳ期、远处转移的患者miR-6861-5p水平,明显高于无淋巴结转移、肿瘤分期Ⅰ~Ⅱ期、无远处转移的患者,差异有统计学意义(P<0.05);低表达组无病生存时间[(31.67±12.02)个月]、总生存时间[(42.89±13.58)个月]均长于高表达组[(22.54±9.75)个月、(34.25±10.88)个月],差异有统计学意义(P<0.05)。结论与健康人群相比,血清miR-6861-5p在原发性肝癌患者中表达水平更高,且与肿瘤分期、转移情况相关,监测其水平变化对评估患者预后有重要意义。 Objective To investigate the level and clinical significance of serum microrna-6861-5p(mir-6861-5p)in patients with primary liver cancer.Methods 60 patients with primary liver cancer were selected as the research object,and 60 healthy people who underwent routine physical examination were selected as the control group.The level of serum mir-6861-5p was detected in all participants.The levels of mir-6861-5p were compared between the 2 groups;All patients with liver cancer were followed up regularly to analyze the relationship between mir-6861-5p and pathological characteristics and survival time.Results The level of serum mir-6861-5p in liver cancer group was(1.90±0.24),which was significantly higher than that in the control group(1.02±0.08)(P<0.05);There was no significant difference in the number of lesions,liver cirrhosis,tumor diameter and serum mir-6861-5p level in patients with viral hepatitis(P>0.05);The level of mir-6861-5p in patients with lymph node metastasis,tumor stageⅢ~Ⅳand distant metastasis was significantly higher than that in patients without lymph node metastasis,tumor stageⅠ~Ⅱand distant metastasis(P<0.05);The disease-free survival time(31.67±12.02)months and the overall survival time(42.89±13.58)months in the low expression group were significantly longer than those in the high expression group(22.54±9.75)months and(34.25±10.88)months(P<0.05).Conclusion Compared with healthy patients,the expression level of serum mir-6861-5p is higher in patients with primary liver cancer,and is related to tumor stage and metastasis.Monitoring the change of serum mir-6861-5p level is of great significance to evaluate the prognosis of patients.
作者 孟春阳 孟玉丽 张红旭 MENG Chunyang;MENG Yuli;ZHANG Hongxu(Luohe Central Hospital,Luohe,462000)
出处 《实用癌症杂志》 2023年第9期1418-1420,共3页 The Practical Journal of Cancer
关键词 原发性肝癌 血清miR-6861-5p 疾病病理特点 预后 Primary liver cancer Serum mir-6861-5p Pathological features of the disease Prognosis
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