摘要
目的探讨血清趋化因子配体3(CCL3)、P选择素(P-selectin)联合检测对急性肺栓塞(APE)的诊断价值。方法选取2020年6月~2022年6月期间本院接诊的90例APE患者作为研究组。另取90例同期在本院体检,且一般资料与APE患者相匹配的健康者作为对照组。采用Pearson法分析APE患者血清CCL3、P-selectin表达水平的相关性;采用Logistic回归分析影响APE发生的相关因素;受试者工作特征(ROC)曲线分析血清CCL3、P-selectin水平对APE的诊断价值。结果研究组血清CCL3、P-selectin水平均显著高于对照组(P<0.05);APE患者血清CCL3、P-selectin表达水平呈正相关(r=0.808,P<0.05);收集所有指标数据的中位数对影响APE发生的相关因素进行单因素分析,结果显示,研究组心率≥90次/min、SBP<120 mmHg和DBP<80 mmHg的患者所占比例显著高于对照组(P<0.05);心率、CCL3及P-selectin均为发生APE的危险因素(P<0.05),SBP、DBP为保护因素(P<0.05);血清CCL3、P-selectin及二者联合诊断APE的曲线下面积(AUC)分别为0.888、0.854和0.951,二者联合优于血清CCL3、P-selectin各自单独诊断(Z_(二者联合-CCL3)=2.146,Z_(二者联合-P-selectin)=2.315,P=0.022、0.039)。结论血清CCL3、P-selectin水平与APE的发生密切相关,二者联合检测对APE具有较好的诊断价值。
Objective To investigate the diagnostic value of combined detection of serum C-C motif chemokine ligand 3(CCL3)and P-selectin in acute pulmonary embolism(APE).Methods A total of 90 patients with APE admitted to our hospital from June 2020 to June 2022 were selected as the study group.Another 90 healthy subjects who underwent physical examination in our hospital during the same period and whose general data matched those of APE patients were selected as the control group.The correlation of serum CCL3 and P-selectin expression levels in APE patients was analyzed by the Pearson method.Logistic regression was used to analyze the related factors affecting the occurrence of APE.The diagnostic value of serum CCL3 and P-selectin levels in APE was analyzed by the receiver operating characteristic(ROC)curve.Results The levels of serum CCL3 and P-selectin in the study group were higher than those in the control group(P<0.05);Serum CCL3 and P-selectin expression levels were positively correlated in APE patients(r=0.808,P<0.05);The median data of all indicators were collected and univariate analysis was performed on the related factors affecting the occurrence of APE.The results showed that the proportion of patients with heart rate≥90/min,SBP<120 mmHg,and DBP<80 mmHg in the study group was significantly higher than that in the control group(P<0.05);heart rate,CCL3,and P-selectin were risk factors for APE(P<0.05),while SBP and DBP were protective factors(P<0.05);the area under the curve(AUC)of serum CCL3,P-selectin,and their combined diagnosis of APE were 0.888,0.854,and 0.951,respectively.The combination of the two was better than that of serum CCL3 and P-selectin alone(Z_(combination-CCL3)=2.146,Z_(combination-P-selectin)=2.315,P=0.022,0.039).Conclusion The levels of serum CCL3 and P-selectin are closely related to the occurrence of APE,and their combined detection has a good diagnostic value for APE.
作者
魏晓丽
李养龙
张琳
WEI Xiaoli;LI Yanglong;ZHANG Lin(Department of Emergency,Affiliated Hospital of Yan′an University,Yan′an,Shaanxi 716000,China)
出处
《临床肺科杂志》
2023年第9期1374-1378,共5页
Journal of Clinical Pulmonary Medicine
关键词
趋化因子配体3
P-选择素
急性肺栓塞
诊断价值
C-C motif chemokine ligand 3
P-selectin
Acute pulmonary embolism
Diagnostic value
