摘要
目的探讨慢性阻塞性肺疾病应用氨茶碱联合常规治疗的临床价值。方法120例慢性阻塞性肺疾病患者,采用随机数字表法分为对照组和观察组,各60例。对照组实施常规治疗,观察组于对照组治疗方案基础上应用氨茶碱治疗。比较两组患者的治疗效果,治疗前后的肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC]、生活质量评分及血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]。结果观察组治疗总有效率为96.67%,高于对照组的86.67%,差异具有统计学意义(P<0.05)。治疗后,两组FEV1、FVC、FEV1/FVC均高于本组治疗前,且观察组FEV1(1.62±0.43)L、FVC(2.70±0.42)L、FEV1/FVC(69.13±9.12)%高于对照组的(1.33±0.38)L、(2.32±0.36)L、(60.22±8.12)%,差异具有统计学意义(P<0.05)。治疗后,两组社会功能、躯体功能、物质生活、心理功能评分均高于本组治疗前,且观察组社会功能、躯体功能、物质生活、心理功能评分分别为(86.06±5.75)、(82.75±4.09)、(81.64±5.43)、(80.70±5.88)分,均高于对照组的(72.42±6.91)、(69.06±6.97)、(68.76±6.75)、(68.86±6.48)分,差异具有统计学意义(P<0.05)。治疗后,两组PaO_(2)高于本组治疗前,PaCO_(2)低于本组治疗前,且观察组PaO_(2)(72.16±17.07)mm Hg(1 mm Hg=0.133 kPa)高于对照组的(64.35±16.22)mm Hg,PaCO_(2)(31.22±7.46)mm Hg低于对照组的(38.59±7.65)mm Hg,差异具有统计学意义(P<0.05)。结论慢性阻塞性肺疾病患者应用氨茶碱联合常规治疗可发挥突出效果,不仅能够改善患者的肺功能和生活质量,同时可纠正患者的血气指标,利于患者病情康复,建议广泛应用在临床中。
Objective To discuss the clinical value of aminophylline combined with routine treatment on chronic obstructive pulmonary disease.Methods A total of 120 patients with chronic obstructive pulmonary disease were divided into control group and observation group according to the random numerical table,with 60 cases in each group.The control group received routine treatment,and the observation group was treated with aminophylline based on the control group.Both groups were compared in terms of therapeutic effects,and the pulmonary function indexes[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC],quality of life score and blood gas indexes[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))]before and after treatment.Results The total effective rate of the observation group was 96.67%,which was higher than that of 86.67%of the control group,and the difference was statistically significant(P<0.05).After treatment,FEV1,FVC and FEV1/FVC in both groups were higher than those before treatment in this group;the observation group had FEV1 of(1.62±0.43)L,FVC of(2.70±0.42)L,and FEV1/FVC of(69.13±9.12)%,which were higher than those of(1.33±0.38)L,(2.32±0.36)L,and(60.22±8.12)%in the control group;the differences were statistically significant(P<0.05).After treatment,the scores of social function,physical function,material life and psychological function in both groups were higher than those before treatment in this group;the scores of social function,physical function,material life and psychological function in the observation group were(86.06±5.75),(82.75±4.09),(81.64±5.43)and(80.70±5.88)points,which were higher than those of(72.42±6.91),(69.06±6.97),(68.76±6.75)and(68.86±6.48)points in the control group;the differences were statistically significant(P<0.05).After treatment,PaO_(2) was higher and PaCO_(2) was lower in both groups than those before treatment in this group;PaO_(2) of(72.16±17.07)mm Hg(1 mm Hg=0.133 kPa)in the observation
作者
岳华芳
徐东峰
张庆迪
YUE Hua-fang;XU Dong-feng;ZHANG Qing-di(Department of Respiratory and Critical Care Medicine,Dongchangfu People's Hospital,Liaocheng 252000,China)
出处
《中国现代药物应用》
2023年第15期11-14,共4页
Chinese Journal of Modern Drug Application
关键词
氨茶碱
常规治疗
慢性阻塞性肺疾病
肺功能
生活质量
血气指标
Aminophylline
Routine treatment
Chronic obstructive pulmonary disease
Pulmonary function
Quality of life
Blood gas indicators
