摘要
目的结合妊娠期糖尿病患者病机病理,应用盐酸二甲双胍联合门冬胰岛素对其实施辅助治疗,对用药后效果以及是否会影响妊娠结局展开分析,便于掌握其用药可行性。方法选取70例妊娠期糖尿病患者,根据随机数字表法分为对照组与研究组,每组35例。对照组单一采取门冬胰岛素治疗,研究组在对照组基础上辅以盐酸二甲双胍治疗。比较两组临床疗效。结果用药前,两组糖化血红蛋白(HbAlc)、空腹血糖(FBG)、餐后2h血糖(2hPG)水平比较,差异无统计学意义(P>0.05);用药后,两组HbAlc、FBG、2hPG水平均低于用药前,且研究组患者低于对照组,差异有统计学意义(P<0.05)。用药前,两组胱抑素C(CysC)、同型半胱氨酸(Hcy)指标比较,差异无统计学意义(P>0.05);用药后,两组患者CysC、Hcy指标均有所下降,但研究组患者下降程度更显著,差异有统计学意义(P<0.05)。研究组、对照组患者用药后不良妊娠发生率分别为2.86%、17.14%,比较差异有统计学意义(P<0.05)。结论盐酸二甲双胍联合门冬胰岛素应用于妊娠期糖尿病治疗中,利于血糖水平控制,改善妊娠结局,值得临床推广与应用。
Objective Combined with the pathogenesis of gestational diabetes mellitus,metformin hydrochloride combined with insulin aspartate was used for adjuvant treatment,and the effect after medication and whether it would affect the pregnancy outcome were analyzed,so as to grasp the feasibility of medication.Methods 70 patients with gestational diabetes mellitus were selected and divided into control group and study group according to random number table method,with 35 cases in each group.The control group was treated with insulin aspartate alone,and the study group was treated with metformin hydrochloride on the basis of control group.The clinical efficacy of the two groups was compared.ResultsBefore treatment,there was no significant difference in the levels of HbAlc,fasting blood glucose(FBG)and 2 h postprandial blood glucose(2 h PG)between 2 groups(P>0.05).After treatment,the levels of HbAlc,FBG and 2 h PG in 2 groups were lower than before treatment,and the study group was lower than the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in cystatin C(CysC)and homocysteine(Hcy)indexes between the two groups(P>0.05).After treatment,the indexes of CysC and Hcy were decreased in both groups,but the decrease was more significant in the study group,with statistical significance(P<0.05).The incidence of adverse pregnancy in the study group and control group was 2.86% and 17.14%,respectively,and the difference was statistically significant(P<0.05).Conclusion The application of metformin hydrochloride combined with insulin aspartate in the treatment of gestational diabetes is beneficial to control blood sugar level and improve pregnancy outcome,and is worthy of clinical promotion and application.
作者
刘强
Liu Qiang(Obstetrics and Gynecology Department,Taizhou People's Hospital,Taizhou 225300,China)
出处
《实用妇科内分泌电子杂志》
2023年第11期50-52,共3页
Electronic Journal of Practical Gynecological Endocrinology
关键词
妊娠期糖尿病
盐酸二甲双胍
门冬胰岛素
妊娠结局
Gestational diabetes mellitus
Metformin hydrochloride
Insulin aspartate
Pregnancy outcome
