摘要
目的:探究抗幽门螺杆菌(Hp)感染在原发性免疫球蛋白A肾病(IgAN)治疗中的价值。方法:选取濮阳市油田总医院2020年2月至2022年8月期间收治的原发性IgAN患者92例作为研究对象,依据随机数字表法分成对照组与观察组,各46例。对照组患者接受常规治疗,观察组患者基于常规治疗加用2周抗Hp感染的四联疗法,比较两组患者的疗效以及治疗前后肾功能指标〔血清肌酐(Scr)、24 h尿蛋白定量(24h-UTP)、血清尿素氮(BUN)、肾小球滤过率(e GFR)〕、肝功能指标〔丙氨酸氨基转移酶(ALT)、天冬门氨酸氨基转移酶(AST)〕、肾活检病理指标变化。结果:与对照组相比较,观察组患者的总有效率明显更高,差异具有统计学意义(P<0.05);治疗后,观察组患者的24h-UTP低于对照组,e GFR高于对照组,差异具有统计学意义(P<0.05);两组患者治疗前后AST、ALT水平比较,差异均无统计学意义(P>0.05);观察组患者炎症细胞浸润、肾小管萎缩发生率均低于对照组,差异具有统计学意义(P<0.05)。结论:抗Hp感染应用于原发性IgAN的临床治疗中可提高治疗效果,改善患者肾功能,改善肾活检病理指标,不影响肝功能。
Objective To explore the value of anti-Helicobacter pylori(Hp)infection in the treatment of primary immunoglobulin A nephropathy(IgAN).Methods A total of 92 patients with primary IgAN admitted to Puyang Oilfield General Hospital from February 2020 to August 2022 were selected as the research objects.According to the random number table method,they were divided into a control group and an observation group,with 46 cases in each group.The control group received conventional treatment,and the observation group received anti-Hp quadruple therapy for 2 weeks based on conventional treatment.The efficacy and renal function indexes before and after treatment[serum creatinine(Scr),24 hours urine total protein(24h-UTP),blood urea nitrogen(BUN),estimated glomerular filtration rate(eGFR)],liver function indexes[alanine transaminase(ALT),aspartate transaminase(AST)],and renal biopsy pathological indexes were compared between the two groups.Results Compared with the control group,the total effective rate of the observation group was significantly higher,and the difference was statistically significant(P<0.05).After treatment,the 24h-UTP of the observation group was lower than that of the control group,and the eGFR was higher than that of the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the levels of AST and ALT between the two groups before and after treatment(P>0.05).The incidences of inflammatory cell infiltration and renal tubular atrophy in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The application of anti-Hp infection in the clinical treatment of primary IgAN can improve the therapeutic effect,improve the renal function of patients,improve the pathological indicators of renal biopsy,and does not affect liver function.
作者
王玉路
薛现军
刘敏洁
侯盈苹
苗月亭
WANG Yu-lu;XUE Xian-jun;LIU Min-jie;HOU Ying-ping;MIAO Yue-ting(Puyang Oilfield General Hospital,Henan Puyang 457000)
出处
《深圳中西医结合杂志》
2023年第11期17-20,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
河南省医学科技攻关项目(LHGJ20200915)。
