摘要
造血干细胞(HSC)归巢到骨髓并植入是临床造血干细移植(HSCT)成功的关键步骤。SDF-1/CXCR4轴被认为是促进HSC归巢的一种非常有前景的靶点。近年来,随着对HSC归巢机制研究的不断深入,学者们探索了核激素受体、组蛋白去乙酰化酶抑制剂、前列腺素以及代谢调节等多种促进HSC归巢和植入的新方法,以提高HSCT的成功率、改善患者的生存。本文就HSC归巢的机制以及促进HSC归巢和植入策略的最新研究进展作一综述。
The homing and engraftment of hematopoietic stem cells(HSC)into bone marrow is the first critical step for successful clinical hematopoietic stem cell transplantation(HSCT).SDF-1/CXCR4 is considered to be a very promising target to promote HSC homing.In recent years,with the in-depth research on the HSC homing,a variety of new strategies for promoting HSC homing and engraftment have been explored,such as nuclear hormone receptor,histone deacetylase inhibitor,prostaglandin and metabolic regulation,so as to increase the success rate of HSCT and improve the survival of patients.In this review,the recent research advances in the mechanism of HSC homing and strategies to promote HSC homing and engraftment were summarized and discussed.
作者
朱萍萍
文瑞婷
杨志刚
ZHU Ping-Ping;WEN Rui-Ting;YANG Zhi-Gang(Department of Hematology,Zhanjiang Central Hospital,Guangdong Medical University,Zhanjiang 524045,Guangdong Province,China)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2023年第4期1229-1232,共4页
Journal of Experimental Hematology
关键词
造血干细胞移植
造血干细胞
归巢
植入
hematopoietic stem cell transplantation
hematopoietic stem cells
homing
engraftment
