摘要
目的比较双相情感障碍(bipolar disorder,BD)患者抑郁发作期、缓解期fMRI特点。方法以2018年3月~2021年3月89例BD抑郁患者为研究对象,根据发病时期不同分为发作期组及缓解期组,并以临床招募志愿者30例为对照组,均给予静息态fMRI检查。应用DPARSF软件分析fMRI数据,并计算全脑的ReHo值、ALFF值,比较三组间的差异。结果发作期组较对照组在右额内侧回、右颞上回、左顶下小叶、左脑岛、左丘脑、右小脑右叶ReHo增强,在右眶部额上回、右前扣带回、后扣带回、右项下小叶ReHo降低(P<0.05);发作期左额上回、右额上回、左顶下小叶、左丘脑、左小脑后叶ALFF增强,右舌回、右海马旁回、右颞中回、右项下小叶、右中央后回ALFF降低(P<0.05);缓解期组较对照组在右颞中回ReHo增强,右顶下小叶、楔前叶ReHo降低(P<0.05);缓解期较对照组在右额内侧回、左顶下小叶、左小脑后叶ALFF增强,右楔叶、右顶下小叶、右额中回ALFF降低(P<0.05);发作期组较缓解期组右颞上回、右颞下回、左颞中回、左额下回、左顶下小叶、左脑岛ReHo增强,左中央后回、左额内侧回、右额中回ReHo降低(t=6.98、4.38、5.12、5.35、5.72、3.95、-4.72、-4.38、-4.11,P<0.05);发作期组较缓解期组左颞下回、右额中回、右顶上回ALFF增强,左小额千叶、左额下回、左后扣带回、右楔前叶、右顶下小叶ALFF降低(t=2.39、2.35、2.48、-2.58、-2.60、-2.75、-2.78、-2.65,P<0.05)。结论BD抑郁发作期、缓解期患者均存在广泛脑区异常激活现象,且发作期患者较缓解期患者存在双侧颞下回、顶下小叶等脑区自发活动异常。
ObjectiveTo compare the characteristics of fMRI in patients with bipolar disorder(BD)during depressive attack and remission stages.Methods a total of 89 patients with BD and depression were enrolled as the research objects between March 2018 and March 2021.according to different onset stages,they were divided into attack-stage group and remission-stage group.And other 30 clinically recruited volunteers were enrolled as control group.all underwent resting-state fMRI examination.The data were analyzed by DPaRSF software.The whole-brain Reho and aLFF values were calculated and compared among the three groups.Results Compared with control group,Reho values of right medial frontal gyrus,superior temporal gyrus,left inferior parietal lobule,left insula,left thalamus and right cerebellum lobe were increased in attack-stage group,while Reho values of right superior frontal gyrus,right anterior cingulate gyrus,posterior cingulate gyrus and right inferior lobule were decreased(P<0.05).Compared with control group,aLFF values of left superior frontal gyrus,right superior frontal gyrus,left parietal inferior lobule,left thalamus and left posterior cerebellum lobe were increased in attack-stage group,while aLFF values of right lingual gyrus,right parahippocampal gyrus,right middle temporal gyrus,right inferior lobule and right central posterior gyrus were decreased(P<0.05).Compared with control group,Reho value of right middle temporal gyrus was increased in remission-stage group,while Reho values of right inferior parietal lobule and precuneus were decreased(P<0.05).Compared with control group,aLFF values of right medial frontal gyrus,left inferior parietal lobule and left posterior cerebellar lobe were increased in remission-stage group,while aLFF values of right cuneiform lobe,right inferior parietal lobule and right middle frontal gyrus were decreased(P<0.05).Compared with remission-stage group,Reho values of right superior temporal gyrus,right inferior temporal gyrus,left middle temporal gyrus,left inferior frontal gyrus,
作者
李宜生
任鑫
柯岩
曹喆
邓晶
Li Yi-sheng;Ren Xin;Ke Yan;Cao Zhe;Deng Jing(Department of Radiology,Second Affiliated Hospital of Hubei University of Science and Technology,Xianning 437100,Hubei Province,China;Radiology Department of Xianning Central Hospital(Tongji Xianning Hospital)Xianning 437199,Hubei Province,China;Cancer Department of Xianning Central Hospital(Tongji Xianning Hospital)Xianning 437199,Hubei Province,China;Department of Imaging,Clinical College,Hubei University of Science and Technology,Xianning 437099,Hubei Province,China)
出处
《中国CT和MRI杂志》
2023年第8期7-9,共3页
Chinese Journal of CT and MRI
基金
湖北省卫生健康委科研立项项目(WJ2019M095)
湖北科技学院校内培育科研项目(2023-24X05)。
关键词
双相情感障碍
抑郁发作期
抑郁缓解期
静息态功能磁共振成像
BipolarDisorder
DepressiveAttackStage
DepressiveRemissionStage
Resting-state FunctionalMagneticResonanceImaging
