摘要
目的探讨分析代谢相关脂肪性肝病(MAFLD)对颈动脉狭窄的影响。方法随机纳入2014年1月1日—2020年6月30日在昆明医科大学第二附属医院消化内科住院期间同时行腹部超声、颈部血管超声的834例患者,收集基线资料、临床诊断,根据病史、临床检验及影像学指标分为MAFLD组(n=469)和非MAFLD组(n=365)。颈动脉按照狭窄程度分为:正常血管、狭窄<50%,狭窄≥50%。符合正态分布的计量资料两组间比较采用成组t检验,不符合正态分布的计量资料两组间比较采用Mann-Whitney U秩和检验;计数资料两组间比较采用χ^(2)检验。采用单因素和多因素Logistic回归分析颈动脉狭窄的影响因素。结果MAFLD组患者颈动脉狭窄≥50%的比例高于非MAFLD患者,差异有统计学意义(10.66%vs 5.21%,χ^(2)=8.050,P=0.005)。单因素Logistic回归分析结果显示,男性患者、吸烟、MAFLD、BMI、TC、HDL、服用降脂药、收缩压、高血压或服药、2型糖尿病、胰岛素抵抗,AST在两组间差异有统计学意义(P值均<0.05)。校正了性别、吸烟、HDL、BMI、高血压病史或服药、2型糖尿病、AST后,多因素Logistic回归分析结果显示MAFLD是颈动脉狭窄≥50%的危险因素(OR=1.979,95%CI:1.055~3.713,P=0.033)。结论MAFLD是颈动脉狭窄≥50%形成的独立危险因素。
Objective To investigate the influence of metabolic associated fatty liver disease(MAFLD)on carotid stenosis.Methods This study was conducted among the patients who underwent abdominal ultrasound and cervical vascular ultrasound at the same time during hospitalization in Department of Gastroenterology,The Second Affiliated Hospital of Kunming Medical University,from January 1,2014 to June 30,2020,and baseline data and clinical diagnosis were collected.According to medical history,clinical tests,and imaging indicators,they were divided into MAFLD group with 469 patients and non-MAFLD group with 365 patients.Carotid artery were assessed as normal carotid artery,carotid stenosis<50%,and carotid stenosis≥50%according to the degree of stenosis.The independent-samples t test was used for comparison of normally distributed continuous data between two groups,and the Mann-Whitney U rank sum test was used for comparison of non-normally distributed quantitative data between two groups;the chi-square test was used for comparison of qualitative data between two groups.The univariate and multivariate logistic regression analyses were used to investigate the influencing factors carotid stenosis.Results Compared with the non-MAFLD group,the MAFLD group had a significantly higher proportion of patients with carotid stenosis≥50%(10.66%vs 5.21%,χ^(2)=8.050,P=0.005).The univariate logistic regression analysis showed that there were significant differences between the two groups in the proportion of male patients,smoking,MAFLD,body mass index(BMI),total cholesterol,high-density lipoprotein(HDL),administration of lipid-lowering drugs,systolic pressure,hypertension or medication,type 2 diabetes,insulin resistance,and aspartate aminotransferase(AST).After adjustment for sex,smoking,HDL,BMI,history of hypertension or medication,type 2 diabetes,and AST,the multivariate logistic regression analysis showed that MAFLD was a risk factor for carotid stenosis(≥50%)(odds ratio=1.979,95%confidence interval:1.055-3.713,P=0.033).Conclusion M
作者
姜梓萌
陈宇航
张志娇
郑梦瑶
李未华
黄华
赵公芳
JIANG Zimeng;CHEN Yuhang;ZHANG Zhijiao;ZHENG Mengyao;LI Weihua;HUANG Hua;ZHAO Gongfang(Department of Gastroenterology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2023年第8期1874-1879,共6页
Journal of Clinical Hepatology
基金
云南省“万人计划”名医人才专项(YNWR-MY-2019-074)。
