摘要
目的:研究死亡相关蛋白激酶1(DAPK1)与急性缺血性脑卒中(AIS)患者病情严重程度的相关性。方法:选择于我院治疗的104例AIS患者为AIS组,另选择同期健康体检者96例为健康对照组,比较两组血清DAPK1水平。依据AIS严重程度,AIS组被分为轻度组(44例)与中/重度组(60例),比较两组一般临床资料、血清DAPK1水平。分析血清DAPK1水平与一般临床资料的相关性、对中重度AIS的预测价值及中重度AIS的影响因素。结果:与健康对照组比较,AIS组血清DAPK1水平显著升高(P=0.001)。与轻度组比较,中/重度组年龄、TC及CRP水平、颈动脉粥样硬化及高血压比例、血清DAPK1水平均显著升高(P<0.05或<0.01)。Pearson及Spearman相关性分析显示,血清DAPK1水平与年龄、颈动脉粥样硬化比例、高血压比例、TC及CRP水平呈显著正相关(r=0.415~0.541,P均=0.001)。ROC曲线显示,血清DAPK1水平预测中重度AIS的曲线下面积为0.853,截断值>2.23ng/L,敏感度为83.33%,特异度为84.09%。多因素Logistic回归分析显示,DAPK1、颈动脉粥样硬化是AIS患者发展为中/重度的独立危险因素(OR=2.784、2.661,P均<0.01)。结论:血清DAPK1水平升高与AIS患者病情加重存在密切联系。
Objective:To study correlation between death associated protein kinase 1(DAPK1) and disease severity in patients with acute ischemic stroke(AIS).Methods:A total of 104 AIS patients treated in our hospital were selected as AIS group.Another 96 healthy volunteers were simultaneously regarded as healthy control group.Serum DAPK1 level was compared between two groups.According to severity of AIS,AIS group was divided into mild group(n=44) and medium/severe group(n=60),and general clinical data and serum DAPK1 level were compared between two groups.Correlation between serum DAPK1 level and general clinical data,predictive value of serum DAPK1 level for medium/severe AIS and influencing factors of medium/severe AIS were analyzed.Results:Compared with healthy control group,there was significant rise in serum DAPK1 level in AIS group,P=0.001.Compared with mild group,there were significant rise in age,levels of TC and CRP,percentages of carotid atherosclerosis and hypertension and serum DAPK1 level in medium/severe group(P0.05 or 0.01).Pearson and Spearman correlation analysis indicated that serum DAPK1 level was significant positively correlated with age,percentages of atherosclerosis and hypertension,levels of TC and CRP(r=0.415~0.541,P=0.001 all).ROC curve indicated that AUC of serum DAPK1 level predicting medium/severe AIS was 0.853,cutoff point was 2.23ng/L,sensitivity was 83.33%and specificity was 84.09%.Multivariate Logistic regression analysis indicated that DAPK1 and carotid atherosclerosis were independent risk factors for AIS patients developing to moderate/severe(OR=2.784,2.661,P0.01 both).Conclusion:Increase of serum DAPK1 level is closely associated with aggravation of AIS patients.
作者
郑柳英
陈勇
侯宇峰
尹兴苗
ZHENG Liu-ying;CHEN Yong;HOU Yu-feng;YIN Xing-miao(Department of Neurology,People's Hospital of Xichang City,Xichang,Sichuan,616650,China)
出处
《心血管康复医学杂志》
CAS
2023年第4期327-330,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
凉山州科技计划重点研发项目(20ZDYF0036)。
