摘要
目的 分析2型糖尿病患者血糖水平与肿瘤标志物癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原199(Carbohydrate antigen199,CA199)与甲胎蛋白(Alpha fetoprotein,AFP)的相关性。方法 选取2019年10月—2022年10月淮安市淮安医院收治的106例2型糖尿病患者为糖尿病组,同时选择同期接受体检的100名健康人员作为对照组,比较两组血糖与肿瘤标志物指标水平,分析血糖水平对CEA、CA199与AFP的影响。结果糖尿病组患者的FPG、HbA1c、CEA、CA199水平均高于对照组,差异有统计学意义(P<0.05)。重度糖尿病患者的CEA、CA199水平均高于轻中度糖尿病患者,差异有统计学意义(P<0.05);相关性分析显示,2型糖尿病患者血糖水平与CEA、CA199呈现为正相关性(r=0.126、0.515,P=0.025、0.032),与AFP无明显相关性(P>0.05)。结论 2型糖尿病患者血糖水平和肿瘤标志物CEA、CA199表达存在明显关联,但与AFP表达无明显关联,可能受到2型糖尿病患者胰腺癌高发的影响。
Objective The correlation between blood glucose level and tumor markers carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199)and alpha fetoprotein(AFP)in patients with type 2 diabetes was analyzed.Methods A total of 106 patients with type 2 diabetes admitted to Huai´an Hospital from of Huai´an city October 2019 to October 2022 were selected as the diabetic group,and 100 healthy people who underwent physical examination dur‐ing the same period were selected as the control group.The levels of blood glucose and tumor markers were compared between the two groups,and the effects of blood glucose levels on CEA,CA199 and AFP were analyzed.Results The levels of FPG,HbA1c,CEA and CA199 in the diabetic group were higher than those in the control group,and the dif‐ference was statistically significant(P<0.05).The levels of CEA and CA199 in patients with severe diabetes were higher than those in patients with mild to moderate diabetes,and the difference was statistically significant(P<0.05).Correlation analysis showed that the blood glucose level of patients with type 2 diabetes was positively correlated with CEA and CA199(r=0.126,0.515,P=0.025,0.032),and had no significant correlation with AFP(P>0.05).Conclusion There was a significant correlation between blood glucose level and the expression of tumor markers CEA and CA199 in patients with type 2 diabetes,but no significant correlation with AFP expression,which may be affected by the high incidence of pancreatic cancer in patients with type 2 diabetes.
作者
操燕红
周康
CAO Yanhong;ZHOU Kang(Department of Laboratory,Huai´an Hospital,Huai´an,Jiangsu Province,223200 China)
出处
《系统医学》
2023年第9期1-4,共4页
Systems Medicine
关键词
2型糖尿病
空腹血糖
餐后2
h血糖
癌胚抗原
糖类抗原199
甲胎蛋白
Type 2 diabetes
Fasting plasma glucose
2-hour postprandial blood glucose
Carcinoembryonic antigen
Carbohydrate antigen 199
Alpha-fetoprotein
