摘要
目的:探讨游离三碘甲腺原氨酸(FT3)/游离甲状腺素(FT4)比值、载脂蛋白B(Apo B)/载脂蛋白A1(Apo A1)比值与急性缺血性脑卒中(AIS)患者临床疗效和出院后短期预后的关系。方法:选取2020年2月至2022年2月安徽省第二人民医院收治的102例AIS患者,所有患者入院后接受血运重建、抗血小板等治疗,根据临床疗效将患者分为有效组(76例)和无效组(26例)。治疗后检测所有AIS患者血清FT3、FT4、Apo B、Apo A1水平,计算FT3/FT4比值、Apo B/Apo A1比值,所有AIS患者出院后随访3个月,根据AIS患者随访期间的预后情况将其分为预后不良组(31例)和预后良好组(71例)。比较不同组间血清FT3、FT4、Apo B、Apo A1水平以及FT3/FT4比值、Apo B/Apo A1比值差异,分析影响AIS患者出院后短期预后的因素。结果:无效组血清FT3水平、FT3/FT4比值低于有效组(P<0.05),血清Apo B水平、Apo B/Apo A1比值高于有效组(P<0.05)。预后不良组血清FT3水平、FT3/FT4比值低于预后良好组(P<0.05),血清Apo B水平、Apo B/Apo A1比值高于预后良好组(P<0.05)。美国国立卫生院神经功能缺损评分(NIHSS评分)高、Apo B/ApoA1比值增高是AIS患者出院后短期预后不良的危险因素(P<0.05),FT3/FT4比值增高是其保护因素(P<0.05)。结论:AIS临床治疗无效和预后不良患者FT3/FT4比值降低,Apo B/ApoA1比值增高,低FT3/FT4比值和高Apo B/ApoA1比值与AIS患者出院后短期预后不良有关。
Objective:To investigate the relationship between free triiodothyronine(FT3)/free thyroxine(FT4)ratio,Apolipoprotein B(Apo B)/Apolipoprotein A1(ApoA1)ratio and clinical efficacy and short-term prognosis after discharge in patients with acute ischemic stroke(AIS).Methods:102 patients with AIS who were admitted to the The Second People's Hospital of Anhui Province from February 2020 to February 2022 were selected.All patients received revascularization,antiplatelet and other treatments after inclusion,and they were divided into an effective group(76 cases)and an ineffective group(26 cases)according to the clinical efficacy.Serum FT3,FT4,Apo B and Apo A1 levels of all patients with AIS were detected after treatment,and FT3/FT4 ratio and Apo B/Apo A1 ratio were calculated.All patients with AIS were followed up for 3 months after discharge.According to the prognosis of patients with AIS during follow-up,patients were divided into poor prognosis group(31 cases)and good prognosis group(71 cases).Serum FT3,FT4,Apo B,Apo A1 levels,FT3/FT4 ratio and Apo B/Apo A1 ratio difference were compared in the different groups,and the factors affecting the short-term prognosis of patients with AIS after discharge were analyzed.Results:The serum FT3 level and FT3/FT4 ratio in the ineffective group were lower than those in the effective group(P<0.05),and the serum Apo B level and Apo B/Apo A1 ratio were higher than those in the effective group(P<0.05).The serum FT3 level and FT3/FT4 ratio in the poor prognosis group were lower than those in the good prognosis group(P<0.05),and the serum Apo B level and Apo B/Apo A1 ratio were higher than those in the good prognosis group(P<0.05).High National Institutes of Health Neurological Deficit Score(NIHSS Score)and increased Apo B/ApoA1 ratio were risk factors for poor short-term prognosis of patients with AIS after discharge(P<0.05),and increased FT3/FT4 ratio was a protective factor(P<0.05).Conclusion:The decrease of FT3/FT4 ratio and the increase of Apo B/ApoA1 ratio in patients with clinical
作者
王洁
陈文清
高俊
陈玉珠
徐素仿
WANG Jie;CHEN Wen-qing;GAO Jun;CHEN Yu-zhu;XU Su-fang(Department of Clinical Laboratory,The Second People's Hospital of Anhui Province,Hefei,Anhui,232200,China)
出处
《现代生物医学进展》
CAS
2023年第13期2508-2512,共5页
Progress in Modern Biomedicine
基金
安徽省卫生健康委科研项目(AHWJ2021a001)。
